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CUL4A — IFI27
Text-mined interactions from Literome
Li et al., Blood 2006
:
These findings indicate that a Cul4A ubiquitin ligase positively regulates proliferation by targeting p27 for degradation and that
Cul4A down-regulation during terminal erythroid differentiation
allows p27 to accumulate and signal cell cycle exit
Miranda-Carboni et al., Genes Dev 2008
(Breast Neoplasms) :
We further demonstrated that both
Cul4A and Cul4B were
required for Wnt induced
p27 ( KIP1 ) degradation and S-phase progression