Luftig et al., Proc Natl Acad Sci U S A 2003
:
LMP1 activates the IkappaB kinase complex and NF-kappaB through two cytoplasmic signaling domains that engage tumor necrosis factor receptor associated factor ( TRAF)1/2/3/5 or TRADD and RIP
Luftig et al., Proc Natl Acad Sci U S A 2004
:
Thus, LMP1 induces typical canonical IKKbeta/IKKgamma dependent, atypical canonical IKKbeta-dependent/IKKgamma independent, and noncanonical NIK/IKKalpha dependent NF-kappaB activations ; NIK/IKKalpha dependent NF-kappaB activation is principally mediated by the LMP1 TRAF binding site
Song et al., Proc Natl Acad Sci U S A 2006
:
Surprisingly, LMP1 expression activated TRAF6 ubiquitination, IKKbeta induction of IkappaB alpha phosphorylation, and p65 nuclear translocation in both WT and IRAK1-deficient I1A 293 cells