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EPHB2 — IGF1R

Text-mined interactions from Literome

Swantek et al., Endocrinology 1999 : Prolonged activation of ERK2 by epidermal growth factor and other growth factors requires a functional insulin-like growth factor 1 receptor
Giacco et al., FASEB J 2006 : Conversely, inhibition of IGF-1 signaling by Ag1024 and expression of a dominant negative IGF-1R mutant selectively reduced the stimulation of ERK1/2 by TAPs and fibroblast released factors, with minor changes of Akt/PKB activity
Allard et al., American journal of physiology. Renal physiology 2007 (Albuminuria...) : The early phase of diabetes was found to be associated with an increase in glomerular expression of IGF1-R , PDGF-R, and TGF-beta-RII and activation of IRS1, Erk 1/2, and Smad 2/3
Papageorgiou et al., Mol Med 2008 (Prostatic Neoplasms) : Because the IGF-1R signaling is probably the most important host tissue ( bone ) metastasis microenvironment related survival signaling for prostate cancer cells, we conclude that rosiglitazone effects on IGF-1R mediated activation of ERK1/2 and AKT could have clinical implications for the management of androgen ablation-refractory and chemotherapy-resistant advanced prostate cancer with bone metastasis
Zhong et al., J Biol Chem 2009 (Neoplasms) : Because IGF1R signaling is involved, PI3K/AKT constitutes only one of the prosurvival pathways that are activated by 2-DG treatment ; we validated that MEK-ERK signaling was also induced in an IGF1R dependent manner in some cancer cell lines
Pandey et al., J Biol Inorg Chem 2010 : Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+ induced ERK1/2 and PKB phosphorylation
Jameson et al., Mol Cancer Ther 2011 (Carcinoma, Squamous Cell...) : In both the cell lines, IGF1R induced Erk , but not Akt, activation was eliminated by gefitinib
Lin et al., EMBO Mol Med 2012 (Adenocarcinoma...) : Trop-2 could attenuate IGF-1R signalling mediated AKT/ß-catenin and ERK activation through a direct binding of IGF1
Baloucoune et al., PloS one 2012 (MAP Kinase Signaling System) : Furthermore, we demonstrate that GB1asa induces ERK1/2 phosphorylation through Gi/o proteins and PLC dependent IGF-1R transactivation
Appleman et al., Mol Cancer Res 2012 : KRAS ( G12D ) - and BRAF ( V600E ) -induced transformation of murine pancreatic epithelial cells requires MEK/ERK stimulated IGF1R signaling
Estañ et al., Biochem Pharmacol 2012 (Leukemia) : In summary 2-DG elicits IGF-1R mediated AMPK inactivation and Akt and ERK activation, which facilitates or restrain apoptosis, respectively
Fujita et al., J Biol Chem 2013 : Inhibitors of IGF1R, Src, AKT, and ERK1/2 did not suppress avß3-IGF-IGF1R ternary complex formation, suggesting that activation of these kinases are not required for ternary complex formation
Shu et al., Cellular oncology (Dordrecht) 2013 (Carcinoma, Hepatocellular...) : Klotho is a tumor suppressor that, through the regulation of IGF-1R phosphorylation and subsequent activation of downstream Akt-p70S6K and ERK signaling, regulates HCC tumor cell proliferation, apoptosis, autophagy and invasion