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PAK1 — RHOA

Text-mined interactions from Literome

Coniglio et al., Mol Cell Biol 2008 (Breast Neoplasms...) : We also found that the depletion of Pak2, but not Pak1 , enhances RhoA activity and that the inhibition of RhoA signaling in Pak2 depleted cells decreases MLC phosphorylation and restores cell invasion
Kosoff et al., J Biol Chem 2013 : Pak2, but not Pak1 , negatively regulates RhoA via phosphorylation of the guanine nucleotide exchange factor GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA stimulation