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IL8 — MUC1

Text-mined interactions from Literome

Smirnova et al., Acta Otolaryngol 2002 (Otitis Media with Effusion) : Dose- ( 2-200 ng/ml ) and time- ( 0-5 days ) response studies of IL-8 induced mucin secretion were carried out ... These results suggest that : ( i ) goblet cells are target cells for the pro-inflammatory cytokines IL-1beta, TNF-alpha and IL-8 and can contribute to the pathogenesis of OME by increasing both the concentration of IL-8 and the secretion of mucin ; and ( ii ) IL-8 stimulates prolonged mucin secretion from goblet cells and may be involved in the maintenance of the disease in the chronic stage
Lu et al., J Immunol 2006 (Pneumonia, Bacterial...) : Expression of MUC1 in HEK293T cells attenuated TLR5 dependent IL-8 release in response to flagellin, which was completely ablated when its cytoplasmic tail was deleted
Bautista et al., J Immunol 2009 : IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells ... In this study, the effects of IL-8 on expression of two major airway mucin genes, MUC5AC and MUC5B, were evaluated
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Imbert-Fernandez et al., Exp Eye Res 2011 : MUC1/B and MUC1/A inhibited IL-8 induction by TNFa at 4 h ... However with 24 h TNFa, MUC1/A increased IL-1ß and IL-8 whereas MUC1/B had no effect on cytokine expression
Kato et al., J Immunol 2012 (Lung Diseases...) : Overexpression of MUC1 in HEK293 cells dramatically reduced Pseudomonas aeruginosa stimulated IL-8 expression and decreased the activation of NF-?B and MAPK compared with cells not expressing MUC1
Kyo et al., Am J Respir Cell Mol Biol 2012 (Inflammation) : Our results showed that : ( 1 ) a lysate of NTHi increased the early release of IL-8 and later production of MUC1 protein by A549 cells in dose dependent and time dependent manners, compared with vehicle control ; ( 2 ) both effects were attenuated after transfection of the cells with a TLR2 targeting small interfering ( si ) RNA, compared with a control siRNA ; ( 3 ) the NTHi induced release of IL-8 was suppressed by an overexpression of MUC1 , and was enhanced by the knockdown of MUC1 ; ( 4 ) the TNF-a released after treatment with NTHi was sufficient to up-regulate MUC1, which was completely inhibited by pretreatment with a soluble TNF-a receptor ; and ( 5 ) primary murine tracheal surface epithelial ( MTSE ) cells from Muc1 knockout mice exhibited an increased in vitro production of NTHi stimulated keratinocyte chemoattractant compared with MTSE cells from Muc1 expressing animals
Guang et al., Frontiers in immunology 2012 : Our prior study showed that ectopic over-expression of MUC1 in human AGS gastric epithelial cells reduced H. pylori stimulated IL-8 production compared with cells expressing MUC1 endogenously
Park et al., Am J Physiol Gastrointest Liver Physiol 2012 : J Biol Chem 285 : 20547-20557, 2010 ) demonstrated that expression of MUC1 in AGS gastric epithelial cells limits Helicobacter pylori infection and reduces bacterial-driven IL-8 production