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MYL7 — RHOA
Pathways - manually collected, often from reviews:
-
KEGG Tight junction:
RHOA
→
MYH1/MYH10/MYH11/MYH13/MYH14/MYH15/MYH2/MYH3/MYH4/MYH6/MYH7/MYH7B/MYH8/MYH9/MYL10/MYL12A/MYL12B/MYL2/MYL5/MYL7/MYL9/MYLPF
(protein-protein, indirect effect)
Text-mined interactions from Literome
Sakurada et al., Circ Res 2003
:
The expression of dominant negative
N19RhoA suppressed Ca2+ induced Thr695 phosphorylation of the 110-kDa regulatory subunit of myosin phosphatase and phosphorylation of
myosin light chain in VSM cells
Sowers et al., Am J Physiol Heart Circ Physiol 2004
(Hypertension...) :
Activated
RhoA and increased reactive oxygen species inhibition of PI3K/Akt signaling results in decreased endothelial cell production of nitric oxide,
increased myosin light chain activation with vasoconstriction, and reduced skeletal muscle glucose transport
Ramachandran et al., Invest Ophthalmol Vis Sci 2010
:
Phosphorylated
myosin light chain ( ppMLC ), a biochemical measure of actomyosin contraction, and
activation of its upstream regulatory molecule
RhoA-GTP were assessed by Western blot analysis
Pagiatakis et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
During contraction, VSMCs modulate calcium sensitivity through
RhoA/ROCK mediated inhibition of the
myosin light chain phosphatase complex ( MLCP )
Wojciak-Stothard et al., Circ Res 2012
(Anoxia...) :
Coordinated activation of RhoA and RhoB maximized the hypoxia induced stress fiber formation caused by RhoB/mammalian homolog of Drosophila diaphanous induced actin polymerization and
RhoA/Rho kinase
induced phosphorylation of
myosin light chain on Ser19
Korkina et al., J Biol Chem 2013
(Neoplasm Invasiveness...) :
In contrast, as expected, depletion of
RhoA inhibits
myosin light chain phosphorylation