Gene interactions and pathways from curated databases and text-mining

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NOS2 — NPPA

Text-mined interactions from Literome

Kiemer et al., Mol Pharmacol 2001 : Recently, we could show that the cardiovascular hormone atrial natriuretic peptide (ANP) inhibits the induction of iNOS in LPS stimulated macrophages via its guanylate cyclase coupled A-receptor
Kiemer et al., Shock 2002 : No effect of ANP on LPS activated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 protein levels, iNOS mRNA expression, nitric oxide, and PGE2 production was observed
Diederen et al., Ophthalmic Res 2008 : The possible role of cGMP in the regulation iNOS gene expression and in the regulation of ANP is discussed
Kiemer et al., J Biol Chem 1998 : 1 ) ANP and dibutyryl-cGMP did not inhibit catalytic iNOS activity measured by the conversion rate of L- [ 3H ] arginine to L- [ 3H ] citrulline in homogenates of LPS treated cells
Iimura et al., Kidney Blood Press Res 1998 : To elucidate the effect of atrial natriuretic peptide (ANP) on cytokine induced nitric oxide ( NO ) production, we examined whether ANP affects IL-1 beta stimulated NO production and inducible NO synthase (iNOS) mRNA expression in cultured rat vascular smooth muscle cells ( VSMC ) ... ANP ( 10 nM to 1 mM ) enhanced the nitrite production and iNOS mRNA expression in the presence of IL-1 beta