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APOB — IL1A

Text-mined interactions from Literome

Liu et al., J Cardiovasc Pharmacol 2012 (Atherosclerosis...) : In the effect of anti-inflammation, AN07 decreases the Ox-LDL stimulated upregulation of interleukin (IL) 1ß and IL-6 ... In addition, AN07 acts synergistically with rosiglitazone and pioglitazone to inhibit the Ox-LDL induced proliferation of human aortic smooth muscle cells and upregulation of cyclin D1, cyclin D3, IL-1ß , and IL-6
Lin et al., PloS one 2013 (Plaque, Atherosclerotic) : In in-vitro experiments showed that ox-LDL induced caspase-1 activation and this activation was required for ox-LDL induced macrophages lysis, IL-1ß and IL-18 production as well as DNA fragmentation
Ku et al., Am J Cardiol 1988 (Arteriosclerosis) : Because oxidized LDL is involved in the transformation of macrophages to foam cells, our data on IL-1 induction by oxidized LDL and the mitogenic effect of IL-1 on aortic smooth muscle cells suggest that activated macrophages play an important role in atherogenesis
Stopeck et al., J Biol Chem 1993 : Tumor necrosis factor-alpha (TNF) and interleukin-1 beta (IL-1) increased LDL binding to HepG2 cells in a dose-responsive manner ... We propose that TNF and IL-1 , acting via distinct signal transduction pathways, increase surface LDL receptors by increasing gene transcription
Li et al., Biol Signals 1996 : Hence MM-LDL is biologically active and may contribute to the early stages of atherogenesis by stimulating the inflammatory cytokine IL-1 and the efficacy of probucol in inhibiting the progression of atherosclerosis may be due , both to its inhibition of IL-1 expression by intimal macrophages, and its prevention of LDL oxidation
De Sanctis et al., Immunology 1997 : CM, VLDL, and LDL did not affect IL-1 alpha secretion
Bhakdi et al., Herz 1998 (Arteriosclerosis...) : In contrast, E-LDL does not stimulate IL-1 or TNF production and is only a weak inducer of IL-6
Rovers et al., Atherosclerosis 1998 (Hyperlipoproteinemia Type II) : In addition, LDL-apheresis inhibited IL-1 and TNF production and the expression of CD11a, CD11b, CD11c and CD14 by the mononuclear cells of FH patients and this may be an additional beneficial effect of LDL-apheresis apart of decreasing LDL concentrations