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CASP1 — CDKN1B

Text-mined interactions from Literome

Zancai et al., Oncogene 2005 : Moreover, overexpression of p45Skp2 in DG75 cells prevents p27Kip1 protein accumulation and promotes resistance to the antiproliferative effects of RA
Yang et al., Leuk Res 2012 (Cell Transformation, Neoplastic...) : AKT1 induces caspase mediated cleavage of the CDK inhibitor p27Kip1 during cell cycle progression in leukemia cells transformed by FLT3-ITD ... Knockdown shRNA against AKT1 reduces cleavage of p27Kip1 , inhibits caspase-3 activation, and is associated with a delay in cell cycle progression ... Taken together, these findings indicate that AKT1 induces caspase mediated cleavage of p27Kip1 , required for G1-S progression in FLT3-ITD cells