◀ Back to CCNE2
CCNE2 — E2F2
Pathways - manually collected, often from reviews:
-
KEGG Cell cycle:
Complex of E2F1-E2F2-E2F3-TFDP1-TFDP2
→
CCNE1/CCNE2
(gene expression, expression)
-
WikiPathways Retinoblastoma (RB) in Cancer:
Complex of TFDP1-E2F2
→
CCNE2/CDC25A/CCNE1/CCND3/CDK1/CCDC6/CCNB1
(mim-transcription-translation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
CCNE2
—
E2F2
(interaction, mapped from kegg_pathways)
-
STRING interaction:
E2F2
—
CCNE2
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Duronio et al., Genes Dev 1995
:
Instead,
cyclin E expression
activates E2F in the CNS
Chiarugi et al., Cell Mol Biol Res 1994
:
Notably, both of the two giant regulators of checkpoint 1 ( i.e., p105RB [ retinoblastoma oncosuppressor encoded protein ] and p53 dependent WAF1/CIP1 ) are influenced by or influence G1 cyclins :
cyclin E/cdk2 kinase complexes hyperphosphorylate p105RB,
induce E2F release, and free G1 exit