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E2F2 — RAC2
Text-mined interactions from Literome
Gille et al., J Biol Chem 1999
:
Activated PI 3-kinase
induces cyclin D(1) transcription and
E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB, and to a lesser extent the Rho family GTPase
Rac
Gjoerup et al., J Biol Chem 1998
(Genetic Predisposition to Disease) :
The inhibitory effect of the cyclin dependent kinase inhibitors, p16(ink4), p21 ( cip1 ), and p27 ( cip ) on
Rac/Cdc42 mediated
E2F transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity ... While the
up-regulation of
E2F transcriptional activity by
Rac or Cdc42, not Rho, suffices for entry into S phase and DNA synthesis in Rat-1 R12 cells, this is clearly not the case in NIH 3T3, where additional requirements must exist