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BAX — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Haddad et al., Biochem Biophys Res Commun 2000
:
Sulfasalazine, a potent and specific inhibitor of
NF-kappaB ,
induced Bax at the expense of Bcl-2, in a p53 dependent manner
Mandal et al., Gastroenterology 2001
(Colorectal Neoplasms) :
BA-induced enhancement of DNA fragmentation and stimulation of
Bax promoter activity were
blocked by the expression of dominant negative mutants of JNK1 or AP1 but not
NF-kappaB
Bentires et al., Bull Mem Acad R Med Belg 2001
(Neoplasms) :
We investigated the
role of
NF-kappa B in the regulation of the pro-apoptotic protein
Bax
McInnis et al., J Pharmacol Exp Ther 2002
(Necrosis) :
Time course studies and experiments with SN50 and M40403 suggest that O ( 2 ) production and
NF-kappaB translocation may be involved in necrosis and apoptosis, but the latter also
requires an increased expression of
Bax
Shou et al., J Neurochem 2002
:
NF-kappaB mediated up-regulation of Bcl-X ( S ) and
Bax contributes to cytochrome c release in cyanide induced apoptosis ...
NF-kappaB , a redox-sensitive transcription factor activated after cyanide treatment, is
responsible for the up-regulation of Bcl-X ( S ) and
Bax ... It was concluded that
NF-kappaB mediated up-regulation of Bcl-X ( S ) and
Bax is involved in regulating cytochrome c release in cyanide induced apoptosis
Poulaki et al., Am J Pathol 2002
(Retinoblastoma) :
We found that
NF-kappaB inhibition
up-regulated Bax ; down-regulated the anti-apoptotic proteins Bcl-2, A1, and cIAP-2 ; and induced loss of the mitochondrial transmembrane potential and caspase independent, calpain dependent apoptosis in Rb cells
Grimm et al., Blood 2005
(Epstein-Barr Virus Infections) :
BAX expression was
regulated by LMP-1 activation of
nuclear factor kappaB (NF-kappaB) via the C-terminal activation region 1 ( CTAR-1 ) and CTAR-2
Orlandi et al., J Biol Chem 2007
:
Inhibiting
NF-kappaB activation through SN50
increased apoptotic rate and
Bax expression in intimal but not in medial SMCs, and successive PLC treatment failed to induce a further increase in apoptotic rate
Mendonca et al., Radiat Res 2007
:
Treatment with 5 microM parthenolide for 48 to 72 h inhibited constitutive
NF-kappaB binding and cell growth, reduced plating efficiency, and induced apoptosis through stabilization of p53 (TP53),
induction of the pro-apoptosis protein
BAX , and phosphorylation of BID
Huang et al., Nan Fang Yi Ke Da Xue Xue Bao 2007
(Carcinoma, Hepatocellular...) :
NF-kappaB P65 siRNA induced obvious cell apoptosis with down-regulated Bcl-2 and
up-regulated Bax expressions
Lee et al., Int J Cancer 2008
(Carcinoma, Squamous Cell...) :
A signal network
involving coactivated
NF-kappaB and STAT3 and altered p53 modulates
BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Shankar et al., Molecular cancer 2008
(Neoplasm Metastasis...) :
In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5,
Bax , Bak, p21/WAF1, and p27/KIP1, and
inhibited the activation of
NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL
De Stefano et al., J Mol Med (Berl) 2009
(Inflammation) :
NF-kappaB blockade
upregulates Bax , TSP-1, and TSP-2 expression in rat granulation tissue
Joyce et al., PLoS Pathog 2009
(Hepatitis C) :
We conclude that HCV contributes to hepatocyte damage and apoptosis by inducing stress and pro-apoptotic
BAX while
preventing the induction of anti-apoptotic
NF-kappaB and BCL-xL, thus sensitizing hepatocytes to apoptosis
Liang et al., J Huazhong Univ Sci Technolog Med Sci 2009
:
The results showed that in G1, G2 and G3 groups, insulin secretion was enhanced with the increase of glucose concentration, and the
NF-kappaB expression was also
increased ( P < 0.05 ), but
Bax activity, Cyt C release and apoptosis rate showed no significant difference among them
Wu et al., Oncol Rep 2010
(Lung Neoplasms...) :
The activated
NF-kappaB not only promoted the proliferation of B16 cells, but also enhanced apoptosis resistance of B16 cells by up-regulating Bcl-2 and Bcl-xL and down
regulating Bax