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MAP3K1 — SPP1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Rangaswami et al., J Biol Chem 2005
(Neoplasm Invasiveness) :
To our knowledge this is first report that
OPN induces
NIK/MEKK1 mediated JNK1 dependent/independent AP-1 mediated pro-MMP-9 activation and regulates the negative crosstalk between NIK/ERK1/2 and MEKK1/JNK1 pathways that ultimately controls the cell motility, invasiveness, and tumor growth
Rangaswami et al., Oncol Rep 2007
(Lung Neoplasms...) :
In contrast,
OPN induces
MEKK1 dependent JNK1 activation that leads to downregulation of ERK1/2 activation