◀ Back to SPP1
CSF2 — SPP1
Text-mined interactions from Literome
Lin et al., Mol Cell Biol 2000
:
Antibody blocking experiments revealed that
OPN produced as a
result of IL-3 or
GM-CSF signaling was secreted into the medium and, through binding to its cell surface receptor, CD44, contributed to the survival promoting activities of these two cytokines
Lin et al., J Biol Chem 2001
:
We have recently demonstrated that the gene encoding the osteopontin (OPN) protein is activated both by interleukin-3 and granulocyte-macrophage colony stimulating factor signaling pathways and that, through binding to the cell surface receptor CD44,
OPN contributes to the survival activities of interleukin (IL)-3 and
GM-CSF ( Lin, Y.-H., Huang, C.-J., Chao, J.-R., Chen, S.-T., Lee, S.-F., Yen, J. J.-Y., and Yang-Yen, H.-F
Koguchi et al., Infect Immun 2002
(AIDS-Related Opportunistic Infections) :
We also examined the regulatory
role of granulocyte-macrophage
colony stimulating factor ( GM-CSF ) in
OPN secretion from P. marneffei stimulated PBMCs. Neutralizing anti-GM-CSF MAb significantly reduced OPN secretion, and treatment with this cytokine induced OPN production from both infected and noninfected PBMCs ... Our results demonstrated that
OPN secreted from monocytes is involved in the production of IL-12 from PBMCs after stimulation with P. marneffei and that OPN production is
regulated by
GM-CSF