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IL12A — IRF7
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Liu et al., J Exp Med 2003
:
Thus,
IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of
IL-12 p35 transcription in synergy with LPS mediated events
Lehtonen et al., Cytokine 2003
:
Both IFN-alpha and
IL-12 strongly
up-regulated IRF-1,
IRF-4 , and IRF-8 mRNA and protein expression
Xiong et al., J Biol Chem 2005
:
Furthermore,
IRF-8 induced
IL-12 p40 synthesis in RAW264.7 cells was enhanced by dominant negative Cbl, and peritoneal macrophages from Cbl-/- mice showed increased IL-12 p40 protein production
Gautier et al., J Exp Med 2005
:
Moreover, analysis of interferon regulatory factors ( IRF ) regulation in moDC suggests a
role for
IRF7/8 in mediating IRF3 independent type I IFN and possibly
IL-12p35 synthesis in response to TLR7/8