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EGFR — FOS
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chen et al., J Biol Chem 2001
(Cell Transformation, Neoplastic) :
Egfr gene deficiency
blocked TPA induced ERK activity and
AP-1 binding activity
Bancroft et al., Int J Cancer 2002
(Carcinoma, Squamous Cell...) :
Recombinant EGF induced
EGFR phosphorylation,
activation of NF-kappaB and
AP-1 reporter genes and IL-8 and VEGF expression, indicating that EGFR can mediate coactivation of both transcription factors and cytokine genes in HNSCC ... We conclude that antagonists of EGFR, PI3K and MEK signal pathways have inhibitory activity against
EGFR induced NF-kappaB and
AP-1 activation, IL-8 and VEGF expression and growth by HNSCC
Li et al., Oncogene 2003
:
Currently, little is known about whether
EGFR or its tyrosine kinase is
necessary for TPA induced
AP-1 activation ... Based on these results, we conclude that TPA induced AP-1 activation requires the basal level-EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine ( 1173 ), whereas both EGFR tyrosine kinase and
EGFR autophosphorylation at Y ( 1173 )
play a critical role in EGF induced
AP-1 activation
Das et al., J Biol Chem 2004
(Breast Neoplasms...) :
Furthermore, OPN induces alpha(v)beta(3)
integrin/EGFR mediated ERK1/2 phosphorylation and
AP-1 activation
Ma et al., Biochem Pharmacol 2005
:
Thus,
EGFR plays a critical role in the interaction between ethanol and
AP-1
Finch et al., Free Radic Biol Med 2006
(Carcinoma, Squamous Cell) :
An
EGF-R inhibitor, AG1478,
blocks the higher
AP-1 transactivation and cell proliferation of the low catalase 6M90 cells
Vlotides et al., Mol Endocrinol 2006
(Pituitary Neoplasms) :
EGF induced
EGFR and ERK1/2 phosphorylation was
followed by rapid MAPK kinase/ERK kinase dependent activation of Elk-1 and
c-Fos
Joo et al., Oncogene 2008
:
Finally,
EGFR transactivation was
involved in the expression of
c-Fos and c-Jun via the extracellular signal regulated kinase signaling cascade
Hsieh et al., J Cell Biochem 2008
:
Moreover, S1P induced
EGFR expression was
inhibited by an
AP-1 inhibitor curcumin and tanshinone IIA
Hsieh et al., Biochim Biophys Acta 2008
:
Moreover, thrombin stimulated
activation of NF-kappaB,
AP-1 , and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC,
EGFR , MEK1/2, AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
Kajanne et al., Int J Oncol 2009
(Prostatic Neoplasms) :
Here, we show that constitutive
AP-1 activity in prostate cancer cells is
dependent on the activities of
EGF-R and PI3K ... Together, the findings show that
AP-1 activity in prostate cancer cells
mediates EGF-R and PI3K signalling, is essential for their proliferation, and confers protection against radiation induced cell death
Oyesanya et al., Molecular cancer 2010
(Neoplasm Invasiveness) :
In ovarian cancer cells highly responsive to LPA, activation of
AP-1 by LPA was
suppressed by inhibition of
EGFR , an effect that could be reversed by co-stimulation of another receptor tyrosine kinase c-Met with hepatocyte growth factor, indicating that LPA mediated activation of AP-1 requires activity of a RTK, not necessarily EGFR
Hwang et al., Mol Nutr Food Res 2011
(Fibrosarcoma...) :
Furthermore, the
EGFR inhibitor
inhibited EGF induced MMP-9 expression, as well as
AP-1 activity and cell migration ... Capsaicin inhibited the EGF induced invasion and migration of human fibrosarcoma cells via
EGFR dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen activated protein kinase ( MAPK ), and
AP-1 signaling, leading to the down-regulation of MMP-9 expression
Saeki et al., Exp Dermatol 2012
:
In the current study, the regulatory relationship between
ErbB receptor activation and
induction of
AP-1 proteins in calcium dependent keratinocyte differentiation was analysed ... The predicted network showed that the
ErbB receptor might
regulate AP-1 protein expression via two pathways : positive regulation by c-MYC and negative regulation by signal transducer and activator of transcription 3 ( STAT3 ) pathways ... Experimental validation analysis revealed that
ErbB receptor inhibition
resulted in defective induction of
AP-1 proteins and suppressed terminal differentiation of keratinocytes
Okimoto et al., Oncogene 1996
:
Regulation of
epidermal growth factor receptor by activated H-ras and V-myc oncogenes in mouse Balb/3T3 cells : possible
roles of
AP-1