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PRKDC — RPA2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: RPA2 — PRKDC Brush et al., Nucleic Acids Res 2000*
• IRef Bind_translation Interaction: RPA2 — PRKDC (experimental interaction detection) Brush et al., Nucleic Acids Res 2000*
• IRef Biogrid Interaction: RPA2 — PRKDC (direct interaction, enzymatic study) Wu et al., Cancer Res 2006*
• IRef Biogrid Interaction: RPA2 — PRKDC (direct interaction, enzymatic study) Zernik-Kobak et al., J Biol Chem 1997*
• IRef Biogrid Interaction: RPA2 — PRKDC (direct interaction, enzymatic study) Chan et al., J Biol Chem 2000*
• IRef Biogrid Interaction: RPA2 — PRKDC (physical association, affinity chromatography technology) Shao et al., EMBO J 1999*
• IRef Biogrid Interaction: RPA2 — PRKDC (direct interaction, pull down) Shao et al., EMBO J 1999*
• IRef Dip Interaction: RPA2 — PRKDC (physical association, coimmunoprecipitation) Shao et al., EMBO J 1999*
• IRef Hprd Interaction: PRKDC — RPA2 (in vitro) Shao et al., EMBO J 1999*, Wang et al., Cancer Res 2001*, Zernik-Kobak et al., J Biol Chem 1997*
• IRef Ophid Interaction: RPA2 — PRKDC (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Iftode et al., Crit Rev Biochem Mol Biol 1999 : RPA is a phosphorylation target for DNA dependent protein kinase (DNA-PK) and likely the ataxia telangiectasia mutated gene (ATM) protein kinase, and recent observations are described that suggest that RPA phosphorylation plays a significant modulatory role in the cellular response to DNA damage
Block et al., Nucleic Acids Res 2004 : However, the relative roles of ATM and DNA-PK in the site-specific DNA damage induced phosphorylation of RPA32 have not been reported
Liu et al., Nucleic Acids Res 2012 : Distinct roles for DNA-PK , ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
Brush et al., Proc Natl Acad Sci U S A 1994 : Studies with the simian virus 40 model system indicate that DNA-PK is required for DNA-replication dependent RPA phosphorylation