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GAST — PTGS2

Text-mined interactions from Literome

Yao et al., Br J Cancer 2002 (Adenocarcinoma...) : Moreover, gastrin leads to approximately a two-fold induction of cyclo-oxygenase-2 promoter activity in transiently transfected cells
Guo et al., J Biol Chem 2002 : Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways ... We report here that gastrin significantly increases the expression of COX-2 mRNA and protein, the activity of the COX-2 promoter, and the release of prostaglandin E ( 2 ) from a rat intestinal epithelial cell line transfected with the CCK-B receptor
Tsuji et al., J Pharmacol Exp Ther 2002 (Stomach Ulcer) : Lansoprazole induces mucosal protection through gastrin receptor dependent up-regulation of cyclooxygenase-2 in rats
Konturek et al., J Physiol Pharmacol 2003 (Carcinoma, Signet Ring Cell...) : This study demonstrates that 1 ) gastrin stimulates the gene and protein expression of COX-2 and HGF in human cultured gastric cancer cells and 2 ) gastrin shows antiapoptotic activity through the upregulation of Bcl-2 and survivin
Slice et al., J Cell Physiol 2003 : Pretreatment with L364,714, the CCK1 receptor specific antagonist did not block COX-2 induction by gastrin
Konturek et al., Dig Dis Sci 2003 (Helicobacter Infections...) : ( 4 ) COX-2, PPARgamma, Bcl-2, and survivin were overexpressed in gastric tumor, but the inhibition of COX-2 activity by Vioxx resulted in a significant reduction in serum and tumor levels of progastrin and gastrin and serum IL-8 and TNF-alpha levels, suggesting that gastrin and proinflammatory cytokines could mediate the up-regulation of COX-2 in gastric cancerogenesis
Abdalla et al., Clin Cancer Res 2004 (Adenocarcinoma...) : Gastrin induced cyclooxygenase-2 expression in Barrett 's carcinogenesis ... Gastrin significantly induced COX-2 , prostaglandin E ( 2 ), and cell proliferation in biopsies and cell lines
Colucci et al., Br J Pharmacol 2005 (Colonic Neoplasms) : Moreover, gastrin-17 enhanced the transcriptional activity of COX-2 gene promoter and stimulated COX-2 expression ... The present results suggest that ( a ) in human colon cancer cells endowed with CCK-2 receptors, gastrin-17 is able to enhance the transcriptional activity of COX-2 gene through the activation of ERK-1/ERK-2- and phosphatidylinositol 3-kinase/Akt dependent pathways ; ( b ) these stimulant actions lead to downstream increments of COX-2 expression, followed by prostaglandin E ( 2 ) production and EP ( 4 ) receptor activation ; ( c ) the recruitment of COX-2/prostaglandin pathways contributes to the growth promoting actions exerted by gastrin-17
Konturek et al., Dig Dis Sci 2006 (Adenocarcinoma...) : We conclude that ( 1 ) distal CRC patients show significantly higher serum progastrin levels than matched healthy controls, confirming that this hormone may be implicated in rectal carcinogenesis ; ( 2 ) CRC patients exhibit significantly higher serum levels of IL-8 and TNF-alpha than healthy controls, probably reflecting more widespread inflammatory reaction in the colonic mucosa in CRC ; ( 3 ) gastrin, COX-2, Bcl-2, survivin, and NFkappa B were overexpressed in CRC tumor compared to intact mucosa, but treatment with CLX significantly reduced serum levels of progastrin and IL-8 and TNF-alpha, which could mediate the up-regulation of COX-2 in CRC ; and ( 4 ) CLX also enhanced expression of COX-2 , while inhibiting the expression of gastrin , Bcl-2, survivin, and NFkappa B, suggesting that COX-2 inhibition might be useful in chemoprevention against CRC, possibly due to suppression of the antiapoptotic proteins and reduction in progastrin induced and NFkappa B-promoted tumor growth
Ansorge et al., Regul Pept 2007 (Colonic Neoplasms) : An upstream CRE-E-box element is essential for gastrin dependent activation of the cyclooxygenase-2 gene in human colon cancer cells ... Gastrin stimulated the PGE2-generation and COX-2-mRNA expression in human Colo-320-B cells potently, obviously by transactivating the COX-2-promoter using a region between - 68 bp and + 70 bp
Huang et al., Regul Pept 2007 (Colonic Neoplasms) : The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro ... The purpose of the present study was to determine whether the activation of CCK-2i4svR by gastrin transactivates the COX-2 promoter in human colon cancer cells and in COS-7 cells ... Our results showed that gastrin transactivates the COX-2 promoter in both Colo320 cells and COS-7 cells expressing the CCK-2i4svR cDNA ... Inhibition of p38 ( MAPK ) pathway using specific inhibitor significantly blocked the gastrin induced COX-2 transactivation
Subramaniam et al., Gastroenterology 2008 (Adenocarcinoma...) : Gastrin induces the expression of cyclooxygenase (COX)-2 and interleukin (IL)-8 ; however, the mechanism ( s ), especially in gastric epithelial cells, is not well understood ... Gastrin induced COX-2 and IL-8 expression in AGS-E cells, which was inhibited by phosphatidylinositol 3' kinase (PI3K) and p38 inhibitors ... Gastrin increased the stability of both COX-2 and IL-8 messenger RNA ( mRNA ) in a p38 dependent manner, the half-life increasing from 31 minutes to 8 hours and approximately 4 hours, respectively ... Gastrin , through p38 activity, also enhanced HuR expression, nucleocytoplasmic translocation, and enhanced COX-2 mRNA binding ... Gastrin differentially induces COX-2 and IL-8 expression at the transcriptional and posttranscriptional levels by PI3K and p38 mitogen activated protein kinase pathways, respectively
Xu et al., Cancer Lett 2013 (Stomach Neoplasms) : Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells