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CTNNB1 — VEGFA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
VEGFA
→
CTNNB1
(increases, VEGFA Activity)
Easwaran et al., Cancer Res 2003*
Evidence: Transfection of normal colon epithelial cells with activated beta-catenin up-regulated levels of VEGF-A mRNA and protein by 250-300%.
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NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer)/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-CDH5-CTNNB1-CTNNA1)
→
VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer)/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-CDH5-CTNNB1-CTNNA1)
→
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
(modification, collaborate)
Carmeliet et al., Cell 1999
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
→
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
(modification, collaborate)
Carmeliet et al., Cell 1999
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
→
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
→
VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
IQGAP1 (IQGAP1)
→
VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
→
VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
Text-mined interactions from Literome
Cohen et al., Am J Physiol 1999
:
VEGF stimulates tyrosine phosphorylation of
beta-catenin and small-pore endothelial barrier dysfunction
Easwaran et al., Cancer Res 2003
(Adenocarcinoma...) :
beta-Catenin regulates
vascular endothelial growth factor expression in colon cancer ... Taken together, our observations indicate a close link between
beta-catenin signaling and the
regulation of
VEGF-A expression in colon cancer
Orlandini et al., J Biol Chem 2003
:
Beta-catenin inversely
regulates vascular endothelial growth factor-D mRNA stability
Ilan et al., Lab Invest 2003
(Cell Transformation, Neoplastic...) :
Interestingly, sequestration of endogenous
VEGF in EOMA cultures
resulted in a dramatic decrease in nuclear
beta-catenin and a reduction in CD1 levels, whereas addition of exogenous VEGF elicited increased nuclear beta-catenin localization and increased CD1 levels in HUVEC
Shao et al., J Biol Chem 2005
(Colonic Neoplasms...) :
Moreover, PGE2 and mutated
beta-catenin stimulated the transcription of cyclin D1 and
vascular endothelial growth factor in a synergistic fashion
Ali et al., J Pharmacol Sci 2006
:
The novel Src kinase inhibitor M475271 inhibits
VEGF induced vascular endothelial-cadherin and
beta-catenin phosphorylation but increases their association ... The findings reveal pretreatment with M475271 significantly inhibits
VEGF induced VE-cadherin and
beta-catenin phosphorylation
Leung et al., J Biol Chem 2006
:
Transfection of a stable form of beta-catenin ( S37A ) or the use of a glycogen synthase kinase 3beta inhibitor to stabilize
beta-catenin induced
VEGF synthesis, whereas small interfering RNA mediated down-regulation of beta-catenin did not, confirming that the effect was beta-catenin-specific
Doyle et al., J Cell Biochem 2009
:
Differential
role of
beta-catenin in
VEGF and histamine induced MMP-2 production in microvascular endothelial cells
Steindl-Kuscher et al., Invest Ophthalmol Vis Sci 2009
:
VEGF , on the other hand,
led to a reduction in cyclin D1 and to an increase in GSK 3beta and
beta-catenin expression which was paralleled by an increase in RPE-specific differentiation markers
Maes et al., EMBO J 2010
:
Increased skeletal
VEGF enhances
beta-catenin activity and results in excessively ossified bones
Yang et al., Invest Ophthalmol Vis Sci 2010
:
In addition, the
VEGF induced transcriptional
activation of
beta-catenin and uPAR expression were blocked by PEDF and by inhibitors of p38 and MEK
Yang et al., Exp Eye Res 2012
:
We have shown previously that p38 inhibitors preserve endothelial barrier function and block
VEGF induced
GSK/beta-catenin signaling