◀ Back to MAPK10
BRAF — MAPK10
Pathways - manually collected, often from reviews:
-
KEGG Hepatitis C:
ARAF/BRAF/RAF1
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
Text-mined interactions from Literome
Dugan et al., J Biol Chem 1999
:
Furthermore, constitutive expression of
B-raf in astrocytoma cells
increased MAPK activation, as seen in neurons, and enhanced proliferation
MacNicol et al., J Biol Chem 2000
:
In Xenopus oocytes, the analogous full-length
B-Raf 14-3-3 binding mutant
blocked progesterone stimulated maturation and the activation of endogenous mitogen activated protein kinase kinase and
mitogen activated protein kinase
Banihashemi et al., Mol Endocrinol 2002
:
These results indicate that the dopamine-D2S receptor couples to distinct G ( i/o ) proteins, depending on the pathway addressed, and suggest a novel Galpha(i)3/Galpha ( o ) -dependent inhibition of
MAPK mediated by c-Raf and
B-Raf dependent inhibition of MAPK/ERK kinase
Yamaguchi et al., Kidney Int 2003
(MAP Kinase Signaling System...) :
Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of ERK and
B-Raf , and
MAPK inhibition by PD98059
blocked the effect of the nucleotide to activate ERK
Namba et al., J Clin Endocrinol Metab 2003
(Carcinoma, Papillary...) :
BRAF mutation associated enhanced cell growth was
suppressed by
MAPK kinase inhibitor, U0126
Trakul et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
Because c-Raf-1 and
B-Raf are both
required for maximal
MAPK stimulation by epidermal growth factor in neuronal and epithelial cell lines, we determined whether RKIP significantly affects MAPK signaling
Mitsutake et al., Endocrinology 2006
(Carcinoma, Papillary...) :
BRAF mediates RET/PTC induced
mitogen activated protein kinase activation in thyroid cells : functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis ... The
requirement for
BRAF in RET/PTC mediated
MAPK activation and gene expression has not been tested functionally ... These data indicate that
BRAF is
required for RET/PTC induced
MAPK activation in thyroid cells and support the notion that BRAF inactivation may be an attractive target for PTCs
Burger et al., Eur Urol 2006
(Microsatellite Instability...) :
The present study investigated
B-RAF mutations, MSI status, and
activation of
MAPK signaling in prostate tumors
Yue et al., Oncogene 2006
:
No changes in the activity of B-Raf were detectable during progesterone induced oocyte maturation, after egg fertilization, or during the early embryonic cell cycle, arguing against a
role for
B-Raf in the mitotic activation of MEK1 and p42
MAPK ... We found that both
B-Raf and C-Raf, but not Mos, are
required for Ras induced MEK1 and p42
MAPK activation
Borysov et al., J Biol Chem 2006
:
B-Raf is
critical for
MAPK activation during mitosis and is regulated in an M phase dependent manner in Xenopus egg extracts ... Furthermore suppression of MAPK feedback at mitosis
enhanced B-Raf activity, whereas constitutive activation of
MAPK at mitosis strongly suppressed B-Raf activity
Kono et al., Mol Cancer Res 2006
(MAP Kinase Signaling System...) :
Because
MAPK pathway
activation via constitutively active mutant forms of
BRAF is common in melanomas, correlation between BRAF function and antigen expression was investigated
Hao et al., Mol Cancer Ther 2007
(Colorectal Neoplasms...) :
These observations suggest that inhibition of
B-Raf activation of
mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase ( MEK ) and the extracellular signal regulated kinase MAPK cascade may be an effective approach for the treatment of RAS and B-RAF mutation positive melanomas and colon carcinomas
Sheridan et al., J Biol Chem 2008
(Melanoma) :
The majority of melanoma associated B-Raf mutations involve a single point mutation, V600E, which results in greatly elevated
B-Raf kinase activity and constitutive
activation of
MAPK/ERK downstream
Knauf et al., Curr Opin Cell Biol 2009
(Disease Progression...) :
In thyroid cancer, this interest is further heightened by new information on the role of activated
BRAF and
MAPK pathway
activation in disrupting iodine transport and thyroid hormonogenesis
Pratilas et al., Clin Cancer Res 2010
(Neoplasms) :
Mitogen activated protein kinase (
MAPK ) pathway activation is a frequent event in human cancer and is often the
result of activating mutations in the
BRAF and RAS oncogenes
Tartaglia et al., Molecular syndromology 2010
:
SHP2 ( encoded by PTPN11 ), SOS1,
BRAF , RAF1 and MEK1 positively
contribute to
RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Gronych et al., J Clin Invest 2011
(Astrocytoma...) :
Recent studies have identified
activation of
MAPK signaling, mainly by oncogenic
BRAF activation, as a hallmark genetic event in the pathogenesis of human PA
Pratilas et al., Curr Top Microbiol Immunol 2012
:
Mitogen Activated Protein Kinase (
MAPK ) pathway activation is a frequent event in human cancer and is often the
result of activating mutations in the
BRAF and RAS oncogenes
Korman et al., Wiley interdisciplinary reviews. Systems biology and medicine 2013
(Melanoma) :
Notably, combined therapies involving selective
BRAF inhibitors ( SBIs ) and other inhibitors of
MAPK dependent or MAPK independent resistance pathways appear particularly promising
Cho et al., Small GTPases 2013
(MAP Kinase Signaling System...) :
BRaf inhibitors paradoxically
activate CRaf and
MAPK signaling in Ras transformed cells
King et al., PloS one 2013
:
In addressing this issue, we showed that concomitant administration of BRAF and MEK inhibitors abrogated paradoxical
BRAF inhibitor
induced MAPK signalling in cells, reduced the occurrence of skin lesions in rats, and enhanced the inhibition of human tumor xenograft growth in mouse models
Denis-Henriot et al., Endocrinology 1998
:
Wild-type Galpha12 overexpression prevented the decrease in
MAPK activity and
induced MEK1, but not
B-Raf , expression