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BCL2 — CA2

Text-mined interactions from Literome

Sun et al., Eur J Oral Sci 2001 (Adenocarcinoma...) : Bcl-2 overexpression did not alter carbachol ( CCh ) -elicited initial increase in cytosolic free Ca2+ concentrations ([Ca2+]i) , but Bcl-XL overexpression dramatically reduced this response
Pinton et al., EMBO J 2001 : To investigate whether this Ca2+ depletion is part of the mechanism of action of Bcl-2, we mimicked the Bcl-2 effect on [Ca2+ ] er by different pharmacological and molecular approaches ... It is therefore concluded that the Bcl-2 dependent reduction of [Ca2+ ] er is an important component of the anti-apoptotic program controlled by this oncogene
Edlich et al., EMBO J 2005 : Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin
Mishra et al., J Biol Chem 2006 : Changes in cytosolic Ca2+ levels regulate Bcl-xS and Bcl-xL expression in spermatogenic cells during apoptotic death ... Using an in vitro spermatogenic cell apoptosis model, this study provides a new insight into the possible role of Ca2+ in regulating the Bcl-xS and Bcl-xL expression ... Therefore, this study proposes a role for Ca2+ in regulation of Bcl-xS and Bcl-xL expression and ultimately cell fate
Zhong et al., J Cell Biol 2006 (Calcium Signaling) : To investigate the effect of Bcl-2 on Ca2+ signaling in T cells, we continuously monitored Ca2+ concentration in Bcl-2 positive and -negative clones of the WEHI7.2 T cell line after T cell receptor ( TCR ) activation by anti-CD3 antibody
Xu et al., Mol Cell Biochem 2007 (Calcium Signaling) : The involvement and potential interdependence of inositol trisphosphate ( IP3 ) receptors and Bcl-2 in the regulation of Ca2+ signaling is not clear
Rong et al., Annu Rev Physiol 2008 (Calcium Signaling) : Recent findings indicate that Bcl-2 interacts with inositol 1,4,5-trisphosphate ( IP3 ) receptor Ca2+ channels on the ER, regulating their opening in response to IP3- and thus inhibiting IP3 mediated Ca2+ signals that induce apoptosis while enhancing Ca2+ signals that support cell survival
Hanson et al., Cell Calcium 2008 (Calcium Signaling) : In particular, Bcl-2 has been demonstrated to inhibit the release of Ca2+ from the endoplasmic reticulum ... However, the mechanism by which Bcl-2 causes reduced Ca2+ release is unclear
Rong et al., Mol Cell 2008 (Calcium Signaling...) : The antiapoptotic protein Bcl-2 inhibits Ca2+ release from the endoplasmic reticulum ( ER )
Seo et al., Exp Mol Med 2009 : Furthermore, Ca2 ( + ) overload and enhanced vulnerability to staurosporine in differentiated cells were prevented by Bcl-XL overexpression
Chattopadhyay et al., Appl Biochem Biotechnol 2010 (Disease Models, Animal...) : The mechanism of action of the anti-apoptotic oncogene Bcl-2 and Ca2+ regulation in ischemia-reperfusion injury is still obscure ... Thus, Bcl-2 dependent reduction of Ca2+ is an important component of the anti-apoptotic program in ischemia-reperfusion injury
Qi et al., Oncogene 1997 (Lymphoma) : Therefore, to determine if the effect of Bcl-2 on cytosolic Ca2+ elevation modulates Ca2+ signaling, we investigated the induction of c-fos by TG in WEHI7.2 mouse lymphoma cells, control transfectants ( WEHI7.2-neo ), and transfectants that stably express a high level of Bcl-2 ( W.Hb12 and W.Hb15 ) ... In summary, the findings indicate that Bcl-2 regulates Ca2+ signaling
Kruman et al., J Neurosci Res 1998 : The caspase inhibitor zVAD-fmk and the anti-apoptotic gene product Bcl-2 prevented the sustained [Ca2+ ] i increase and ROS accumulation induced by staurosporine indicating that caspases act very early in the apoptotic process
Ichimiya et al., Am J Physiol 1998 : To test this hypothesis, we examined the effect of oxidant treatment on viability in normal rat kidney (NRK) cells and in NRK cells stably transfected with Bcl-2 in the presence or absence of intracellular Ca2+, and we compared the effect of Bcl-2 expression on oxidant induced intracellular Ca2+ mobilization and on ER and mitochondrial Ca2+ pools