◀ Back to CXCL12
CXCL12 — CXCR2
Pathways - manually collected, often from reviews:
-
KEGG Chemokine signaling pathway:
CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2
→
CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1
(protein-protein, activation)
-
Reactome Reaction:
CXCR2
→
CXCL12
(reaction)
Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994
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WikiPathways Chemokine signaling pathway:
CCL19/CCL27/CXCL3/CXCL10/XCL1/CXCL9/CCL21/CCL1/CCL11/CCL7/CCL17/CCL20/CCL22/CCL25/CCL27/CCL3/CCL4/CCL5/CCL15/CCL7/CCL15/CXCL3/CXCL5/CX3CL1/CXCL12/CCL19/CCL26/CXCL13/CXCL11/CCL24/PF4/CCL28/CXCL14/PPBP/CCL21/CXCL16
→
CXCR5/CCR6/CXCR2/CXCR3/CXCR4/CCR1/CCR9/CCR1/CCR3/CCR2/CCR4/CCR2/CCR7/CCR8/CCR10/CX3CR1/CXCR2/XCR1/CXCR6
(activation)
Text-mined interactions from Literome
Amara et al., J Biol Chem 1999
:
Importantly, the amino-terminal domain of
SDF-1alpha which is required for binding to, and
activation of,
CXCR4 remains exposed after binding to HS and is recognized by a neutralizing monoclonal antibody directed against the first residues of the chemokine
Heidemann et al., J Biol Chem 2003
:
Angiogenic effects of interleukin 8 (
CXCL8 ) in human intestinal microvascular endothelial cells are
mediated by
CXCR2
Rios-Santos et al., Am J Respir Crit Care Med 2007
(Disease Models, Animal...) :
The NO donor S-nitroso-N-acetyl-d, l-penicillamine inhibited
CXCL8 induced human neutrophil chemotaxis and
CXCR2 expression on human and murine neutrophils
Neel et al., J Cell Sci 2007
:
Expression of RhoB T19N and transfection of RhoB siRNA impaired sorting of CXCR2 to the lysosome after 3 hours of CXCL8 stimulation and impaired
CXCL8 induced
CXCR2 degradation ... In cells expressing the RhoB Q63L mutant, CXCR2 recycling through the Rab11a recycling compartment was impaired after 30 minutes of CXCL8 stimulation as was
CXCL8 induced
CXCR2 degradation
Hu et al., Circulation 2007
(Anoxia...) :
In isolated myocytes,
CXCR4 activation by
SDF-1alpha resulted in increased phosphorylation of both ERK 1/2 and AKT and decreased phosphorylation of JNK and p38
Sierro et al., Proc Natl Acad Sci U S A 2007
:
CXCL12 did not
induce signaling through CXCR7 ; however,
CXCR7 formed functional heterodimers with CXCR4 and enhanced CXCL12 induced signaling
Gouwy et al., J Leukoc Biol 2009
:
In turn, the induced
CXCL8 synergized with CCL2 for mononuclear cell chemotaxis, and the chemotactic effect was
mediated by
CXCR1/CXCR2 , because CXCL8 receptor antagonists or antibodies were capable of blocking the synergy, while keeping the responsiveness to CCL2 intact
Nasser et al., J Immunol 2009
:
CXCL8 ( also known as IL-8 )
activates CXCR1 and
CXCR2 to mediate neutrophil recruitment and trigger cytotoxic effect at sites of infection
Duda et al., Clin Cancer Res 2011
(Neoplasms) :
CXCL12 ( SDF1alpha )
-CXCR4/CXCR7 pathway
inhibition : an emerging sensitizer for anticancer therapies ?
Singh et al., Microvasc Res 2011
:
Additionally, we examined the mechanism of
CXCL8 dependent CXCR1 and/or
CXCR2 mediated phenotypic changes by evaluating ERK phosphorylation and cytoskeletal rearrangement and observed inhibition of ERK phosphorylation and cytoskeletal rearrangement in HMEC-1-shCXCR1, HMEC-1-shCXCR2 and HMEC-1-shCXCR1/2 cells
Mueller et al., PloS one 2013
(Immunologic Deficiency Syndromes...) :
Upon
stimulation by the endogenous ligand
CXCL12 ,
CXCR4 becomes phosphorylated at multiple sites in its C-terminal domain