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CDH1 — SMAD4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Reinacher-Schick et al., J Pathol 2004
(Colorectal Neoplasms...) :
To assess the
role of
Smad4 in
E-cadherin regulation in colorectal carcinogenesis further, the present study has analysed Smad4 and E-cadherin RNA and protein expression in colorectal carcinoma cell lines and in 51 late-stage colorectal carcinomas ... In primary tumours, loss of Smad4 expression correlated highly significantly with loss of E-cadherin expression, thus providing further evidence for
involvement of the tumour suppressor
Smad4 in the control of expression of the tumour and invasion suppressor
E-cadherin
Medici et al., Mol Biol Cell 2006
:
However, our results also demonstrate that a complete loss of
E-cadherin and transformation to the mesenchymal phenotype are
dependent on
Smad signaling, which subsequently stimulates formation of beta-catenin/LEF-1 complexes that induce EMT
Takano et al., J Biochem 2007
(Pancreatic Neoplasms) :
Smad4 is
essential for down-regulation of
E-cadherin induced by TGF-beta in pancreatic cancer cell line PANC-1 ... To investigate the roles of Smad4 deficiency in invasive and matastatic capabilities of pancreatic cancer, we examined the
effects of
Smad4 deficiency on regulation of the invasion suppressor
E-cadherin in pancreatic cancer cell line PANC-1 ... Thus,
Smad4 mediates down-regulation of
E-cadherin induced by TGF-beta in PANC-1 cells, at least in part, through Snail and Slug induction
Tian et al., Biochem Biophys Res Commun 2009
(Carcinoma...) :
Up-regulation of
Smad4 also
increased the expression of
E-cadherin and decreased the transcriptional activity of beta-catenin/Tcf target genes, such as claudin-1 and MMP-7
Chen et al., BMB Rep 2010
(Carcinoma...) :
The stable expression of
Smad4 increased the expression of
E-cadherin , reduced the expression of plasminogen activator inhibitor-1 ( PAI-1 ) and slightly down-regulated the expression of VEGF ... The stable expression of
Smad4 increased the expression of
E-cadherin , reduced the expression of plasminogen activator inhibitor-1 ( PAI-1 ) and slightly down-regulated the expression of VEGF