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FGF21 — FGFR3

Pathways - manually collected, often from reviews:

• KEGG MAPK signaling pathway: FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9 → FGFR1/FGFR2/FGFR3/FGFR4 (protein-protein, activation)
• KEGG Pathways in cancer: FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9 → FGFR1/FGFR2/FGFR3 (protein-protein, activation)
• WikiPathways ESC Pluripotency Pathways: FGF1/FGF16/FGF6/FGF19/FGF22/FGF10/FGF9/FGF20/FGF11/FGF17/FGF18/FGF14/FGF23/FGF5/FGF2/FGF12/FGF21/FGF3/FGF7/FGF8/FGF4 → FGFR1/FGFR3/FGFR4/FGFR2 (activation)
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: FGF21 — FGFR3 (interaction, mapped from grid intact)
• STRING interaction: FGFR3 — FGF21 (interaction, mapped from grid kegg_pathways dip)

Text-mined interactions from Literome

Wang et al., Growth Factors 2000 : The biological activities of fibroblast growth factors ( FGF ) are mediated by specific cell membrane receptors ( FGFR ), which have three immunoglobulin-like IgG domains in the extracellular region
Pellegrini et al., Curr Opin Struct Biol 2001 : Fibroblast growth factors ( FGFs ) are among the best studied heparin binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR
Anderson et al., J Neurochem 2005 : Dendrimeric FRM peptide was 125-fold more active and stimulated FGFR activation, FGFR dependent and FGF-mimetic neurite outgrowth and cell survival ( but not proliferation )
Buratini et al., Biol Reprod 2007 : Whereas many FGFs activate several FGF receptors, FGF7 and FGF10 primarily activate only one, FGFR2B
Li et al., Mol Cell Endocrinol 2012 : In 3T3-L1 adipocytes, the up-regulation of FGF-21markedly increased GUR, decreased intracellular triglyceride ( TG ) content, up-regulated ß-klotho, FGFR1 , GLUT-1, IRS-1, ATGL, HSL, and ap2 mRNA expressions ( p < 0.05 ) ... In hepatocyte, FGF-21 up-regulation reduced HMGR and PEPCK mRNA expression and increased ß-klotho, FGFR4 and LDLr expression ( p < 0.05 ), whereas down-regulation had the opposite effects
Yie et al., Chem Biol Drug Des 2012 : The endocrine fibroblast growth factor 21 (FGF21) requires both fibroblast growth factor receptor ( FGFR ) and ß-Klotho for signaling
Ahmad et al., Biochim Biophys Acta 2012 (Cell Transformation, Neoplastic...) : FGF signalling mediated by FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in malignancy
Itoh et al., Development 1996 : These results suggest that the FGFR mediated FGF signaling ( 1 ) blocks terminal differentiation of myogenic cells within the somite and ( 2 ) sustains myoblast migration to limb buds from the somite, and that ( 3 ) down-regulation of FGFRs or FGFR signaling is involved in mechanisms triggering terminal differentiation of the limb muscle mass during avian embryogenesis
Santos-Ocampo et al., J Biol Chem 1996 : Significantly, FGF-9 also binds to and activates the `` b '' splice form of FGFR3 , thus becoming the first FGF ligand besides FGF-1 to activate this highly specific member of the FGF receptor family
McKeehan et al., Prog Nucleic Acid Res Mol Biol 1998 : Divalent cations cooperate with the FGFRHS to conformationally restrict FGFRTK trans-phosphorylation, which causes depression of kinase activity and facilitates appropriate activation of the FGFR complex by FGF