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CD55 — VEGFA

Text-mined interactions from Literome

Mason et al., Arthritis Rheum 2001 (Neovascularization, Pathologic) : Because vascular endothelial growth factor ( VEGF ) is cytoprotective to endothelium and is expressed at sites of chronic inflammation, we hypothesized that VEGF may induce DAF expression during inflammatory angiogenesis ... Although VEGF induced EC proliferation was inhibited by both p38 and p42/44 mitogen activated protein kinase ( MAPK ) antagonists, DAF up-regulation in response to VEGF was only sensitive to inhibition of p38 MAPK ... The up-regulation of DAF expression by VEGF may represent an important mechanism for the protection of EC from complement mediated injury during angiogenesis in inflammatory rheumatic diseases
Mason et al., Am J Physiol Cell Physiol 2002 : In contrast, although PKC antagonists inhibited VEGF induced DAF expression, bFGF induced DAF was unaffected ... Investigation of mitogen activated kinase ( MAPK ) pathways also revealed differences, with bFGF induced DAF dependent on p44/42 and p38 MAPK and VEGF requiring activation of p38 MAPK alone
Morgan et al., Tissue Antigens 2002 (Colorectal Neoplasms...) : This study investigated the effects of VEGF on CD55 deposition into matrix and the release of CD55 by metalloproteinases ... In contrast to inflammatory cytokines, CD55 was up-regulated by VEGF at the cell surface and within the extracellular matrix ( ECM )
Mason et al., J Biol Chem 2004 : Use of PKC agonists and isozyme-specific pseudosubstrate peptide antagonists suggested a role for PKCalpha and -epsilon in VEGF mediated DAF up-regulation ... This was confirmed by transfection of ECs with PKCalpha and -epsilon dominant negative constructs, which in combination completely abrogated induction of DAF by VEGF ... The widely used immunosuppressive drug cyclosporin A ( CsA ) inhibited DAF induction by VEGF in a dose dependent manner ... The VEGF induced DAF expression was functionally effective, significantly reducing complement mediated EC lysis, and this cytoprotective effect was reversed by CsA