Gene interactions and pathways from curated databases and text-mining

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CIITA — EPHB2

Text-mined interactions from Literome

Yao et al., J Immunol 2006 (MAP Kinase Signaling System) : ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages
Voong et al., J Biol Chem 2008 : In contrast, inhibition of ERK1/2 activity had little effect on serine-to-alanine mutant forms of CIITA ... These data suggest a model whereby ERK1/2 mediated phosphorylation of CIITA down-regulates CIITA activity by priming it for nuclear export, thus providing a means for cells to tightly regulate the extent of antigen presentation