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BCR — GRB2

Pathways - manually collected, often from reviews:

• BioCarta bcr signaling pathway: B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Pathways in cancer: ABL1/BCR → GRB2 (protein-protein, activation)
• KEGG Chronic myeloid leukemia: ABL1/BCR → GRB2 (protein-protein, activation)
• Reactome Reaction: BCR → GRB2 (indirect_complex) Demiroglu et al., Blood 2001, Sattler et al., Cancer Cell 2002*, Roumiantsev et al., Cancer Cell 2004
• Reactome Reaction: BCR → GRB2 (reaction) Demiroglu et al., Blood 2001, Sattler et al., Cancer Cell 2002*, Roumiantsev et al., Cancer Cell 2004

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BCR — GRB2 (direct interaction, two hybrid) Gaston et al., Exp Hematol 2004*
• IRef Biogrid Interaction: BCR — GRB2 (direct interaction, pull down) Gaston et al., Exp Hematol 2004*
• IRef Biogrid Interaction: BCR — GRB2 (physical association, affinity chromatography technology) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Biogrid Interaction: BCR — GRB2 (direct interaction, two hybrid) Bai et al., Oncogene 1998*
• IRef Biogrid Interaction: BCR — GRB2 (physical association, affinity chromatography technology) Bisson et al., Nat Biotechnol 2011
• IRef Biogrid Interaction: BCR — GRB2 (direct interaction, far western blotting) Million et al., Mol Cell Biol 2004*
• IRef Biogrid Interaction: BCR — GRB2 (physical association, affinity chromatography technology) Million et al., Blood 2000*
• IRef Biogrid Interaction: BCR — GRB2 (physical association, affinity chromatography technology) Million et al., Mol Cell Biol 2004*
• IRef Biogrid Interaction: BCR — GRB2 (physical association, affinity chromatography technology) Puil et al., EMBO J 1994*
• IRef Biogrid Interaction: BCR — GRB2 (physical association, affinity chromatography technology) Ma et al., Oncogene 1997*
• IRef Biogrid Interaction: BCR — GRB2 (direct interaction, pull down) Puil et al., EMBO J 1994*
• IRef Biogrid Interaction: BCR — GRB2 (direct interaction, pull down) Maru et al., Mol Cell Biol 1995*
• IRef Biogrid Interaction: BCR — GRB2 (physical association, affinity chromatography technology) Maru et al., Mol Cell Biol 1995*
• IRef Hprd Interaction: BCR — GRB2 (in vivo) Puil et al., EMBO J 1994*, Ma et al., Oncogene 1997*
• IRef Hprd Interaction: BCR — GRB2 (in vitro) Puil et al., EMBO J 1994*, Ma et al., Oncogene 1997*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Million et al., Mol Cell Biol 2004*
• IRef Intact Interaction: GRB2 — BCR (association, coimmunoprecipitation) Million et al., Blood 2000*
• IRef Intact Interaction: GRB2 — BCR (association, coimmunoprecipitation) Li et al., EMBO J 2001*
• IRef Intact Interaction: GRB2 — BCR (association, anti bait coimmunoprecipitation) Li et al., EMBO J 2001*
• IRef Intact Interaction: GRB2 — BCR (association, pull down) Puil et al., EMBO J 1994*
• IRef Intact Interaction: GRB2 — BCR (association, coimmunoprecipitation) Puil et al., EMBO J 1994*
• IRef Intact Interaction: GRB2 — BCR (association, pull down) Ma et al., Oncogene 1997*
• IRef Intact Interaction: GRB2 — BCR (association, pull down) Li et al., J Biol Chem 1996*
• IRef Intact Interaction: GRB2 — BCR (association, pull down) Jain et al., Oncogene 1997*
• IRef Intact Interaction: GRB2 — BCR (association, pull down) Trüb et al., J Biol Chem 1997*
• IRef Ophid Interaction: GRB2 — BCR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Harmer et al., J Biol Chem 1999 : Here, we report that cross linking of the BCR induces association between Grb2 and SHIP as well as association between Shc and SHIP
Ingham et al., J Immunol 1999 : We found that both the SH2 domain and phosphotyrosine binding (PTB) domain of Shc are important for BCR induced tyrosine phosphorylation of Shc and the subsequent binding of Grb2 to Shc
Ingham et al., J Biol Chem 2001 : Gab1 expression also increased BCR induced tyrosine phosphorylation of SHP2 as well as the binding of Grb2 to SHP2
Gaston et al., Exp Hematol 2004 : In a yeast three-hybrid assay, Grb2 mediated an interaction between Cbl and Bcr-Abl that was dependent on a functional Grb2 binding site ... Grb2 or another, yet unidentified, protein may mediate an initial interaction between Cbl and Bcr-Abl that is independent of Cbl tyrosine phosphorylation
Modi et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : The adapter protein growth factor receptor binding protein-2 ( Grb2 ) can bind phosphorylated BCR/ABL-Y177 , induce Grb2-SoS complex formation and activate Ras signaling
Maru et al., Mol Cell Biol 1995 (Cell Transformation, Neoplastic) : Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS ... Tyrosine phosphorylation of BCR in v-fps transformed cells induced its association with GRB-2/SOS , the RAS guanine nucleotide exchange factor complex
Smit et al., Oncogene 1996 (Burkitt Lymphoma) : B-cell antigen receptor (BCR) stimulation induces tyrosine phosphorylation of the Shc adaptor protein and its association with Grb2 ... We reveal here an additional complexity of the BCR induced Shc/Grb2 complex : it contains tyrosine phosphorylated proteins of 130, 110 and 75 kDa ... In summary, we observe that the BCR activates Shc/Grb2- , Grb2- and Crk adaptor complexes of distinct composition, which may allow selective coupling to different signal transduction cascades