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BCR — CD72

Text-mined interactions from Literome

Adachi et al., J Immunol 2000 (Calcium Signaling...) : These results indicate that CD72 negatively regulates BCR signaling
Adachi et al., J Biol Chem 2001 : Here we demonstrate that, in the BCR expressing myeloma line J558L mu 3, CD72 expression reduces the BCR ligation induced phosphorylation of the BCR component Ig alpha/Ig beta and its cytoplasmic effectors Syk and SLP-65 ... Taken together, BCR induced SHP-1 activation is likely to require inhibitory co-receptors such as CD72, and SHP-1 appears to mediate the negative regulatory effect of CD72 on BCR signaling by dephosphorylating Ig alpha/Ig beta and its downstream signaling molecules Syk and SLP-65
Li et al., Arthritis Rheum 2008 (Autoimmune Diseases) : Biochemical analyses indicated that in anergic B cells, CD72 dominantly down-regulated BCR signaling to limit the antigen induced elevation in [ Ca2+ ] i and the activation of NFATc1, NF-kappaB, MAPK, and Akt ... Mechanistically, CD72 was associated with, and regulated, the molecular adaptor Cbl-b in anergic B cells, suggesting that Cbl-b may play a role in mediating the negative effects of CD72 on BCR signaling
Xu et al., J Immunol 2013 (Autoimmune Diseases...) : We further demonstrated that Cd72(c) is a hypofunctional allele in BCR signal inhibition and that CD72 deficiency induces severe autoimmune disease in the presence of Fas ( lpr )
Adachi et al., J Immunol 1998 : Moreover, cross linking of B cell Ag receptor (BCR) enhances both tyrosine phosphorylation of CD72 and association of CD72 with SHP-1 in B cell line WEHI-231