◀ Back to EIF4E
EIF4E — EIF4H
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
EIF4E
→
EIF4H
(reaction)
Pestova et al., Nature 2000, Asano et al., Genes Dev 2000, Chakrabarti et al., J Biol Chem 1991, Peterson et al., J Biol Chem 1979, Trachsel et al., J Mol Biol 1977, Benne et al., J Biol Chem 1978
-
Reactome Reaction:
EIF4E
→
EIF4H
(indirect_complex)
Trachsel et al., J Mol Biol 1977, Benne et al., J Biol Chem 1978, Grifo et al., J Biol Chem 1983, Pestova et al., Nature 1998, Imataka et al., EMBO J 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Pilipenko et al., Genes Dev 2000
:
Reconstitution of initiation using fully fractionated translation components indicated that
48S complex formation on both IRESs
requires eIF2, eIF3, eIF4A, eIF4B,
eIF4F , and the pyrimidine tract binding protein (PTB) but that the FMDV IRES additionally requires ITAF ( 45 ), also known as murine proliferation associated protein ( Mpp1 ), a proliferation dependent protein that is not expressed in murine brain cells
Hiremath et al., J Biol Chem 1989
:
However, in the
presence of edeine or guanylyl imidodiphosphate, both of which cause accumulation of
48 S initiation complexes,
eIF-4E was detected in the 48 S region