◀ Back to MAPK11
MAPK11 — PPARGC1A
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling mediated by p38-alpha and p38-beta:
p38alpha-beta-active (MAPK14/MAPK11)
→
PGC1 (PPARGC1A)
(modification, activates)
Puigserver et al., Mol Cell 2001*
Evidence: mutant phenotype, assay, reporter gene
-
Reactome Reaction:
MAPK11
→
PPARGC1A
(reaction)
Blanco-Aparicio et al., J Cell Biol 1999*, Knutti et al., Proc Natl Acad Sci U S A 2001*, Wright et al., J Biol Chem 2007*, Gibala et al., J Appl Physiol 2009*, Little et al., Am J Physiol Regul Integr Comp Physiol 2011*, Jiang et al., J Biol Chem 1997*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
PPARGC1A
—
MAPK11
(interaction, mapped from kegg_pathways)
-
STRING interaction:
MAPK11
—
PPARGC1A
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Rasbach et al., J Biol Chem 2007
(Reperfusion Injury) :
Additional inhibitor studies revealed that the sequential activation of Src, p38 MAPK, EGFR, and p38
MAPK regulate the expression of
PGC-1alpha following oxidant injury
Luo et al., J Mol Neurosci 2009
(Reperfusion Injury) :
At the same time, PD98059 ( ERK MAPK inhibitor ) and SB203580 ( P38 MAPK inhibitor ) also prevented the up-regulation of
PGC-1alpha in OGD neurons and MK801 can
inhibit the expression of P38 and ERK
MAPK