◀ Back to TLR2

SIGIRR — TLR2

Text-mined interactions from Literome

Lech et al., Kidney Int 2007 : The lack of TIR8/SIGIRR does not enhance TLR/IL-1R signaling in tubular epithelial cells as was observed in monocytes ... TIR8/SIGIRR does not suppress TLR signaling in tubular epithelial cells, which supports their role as sensors of microbial infection in the kidney
Noris et al., J Immunol 2009 (Acute Disease...) : In this study, we tested the hypothesis that Toll-IL-1R8 (TIR8) , a negative regulator of TLR/IL-1R highly expressed in the kidney, modulates immune cell activation underlying kidney rejection
Lech et al., J Pathol 2010 (Genetic Predisposition to Disease...) : Hence, we hypothesized that TIR8/SIGIRR , an endogenous TLR inhibitor , prevents oil induced SLE
Khan et al., J Immunol 2010 : In this study, we investigated the role of Sigirr in regulating epithelial-specific TLR responses and characterized its expression in colonic biopsy specimens
Sham et al., PLoS Pathog 2013 : One reason for the innate hypo-responsiveness of IEC is their expression of Single Ig IL-1 Related Receptor (SIGIRR) , a negative regulator of interleukin (IL)-1 and TLR signaling