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SAA1 — TLR2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Endogenous TLR signaling: TLR1 (TLR1) → SAA1/TLR2/TLR1 complex (TLR2-TLR1-SAA1) (modification, collaborate)
  Cheng et al., J Immunol 2008*, He et al., Blood 2009*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Endogenous TLR signaling: SAA1/TLR2/TLR1 complex (TLR2-TLR1-SAA1) → SAA1 (SAA1) (modification, collaborate) Cheng et al., J Immunol 2008*, He et al., Blood 2009*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Endogenous TLR signaling: SAA1/TLR2/TLR1 complex (TLR2-TLR1-SAA1) → TLR2 (TLR2) (modification, collaborate) Cheng et al., J Immunol 2008*, He et al., Blood 2009*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Endogenous TLR signaling: SAA1 (SAA1) → TLR2 (TLR2) (modification, collaborate) Cheng et al., J Immunol 2008*, He et al., Blood 2009*
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Matsumura et al., J Leukoc Biol 2004 : These results also demonstrate the disparity between IL-1alpha and TGF-beta in regulating TLR2 mediated SAA production in hepatocytes
Chen et al., Am J Respir Crit Care Med 2010 (Disease Models, Animal...) : The effect of serum amyloid A on nuclear factor (NF)-kappaB induction, cytokine expression, and Toll-like receptor-2 stimulation was determined with transformed human cell lines and bronchoalveolar lavage cells from patients with sarcoidosis
Ather et al., J Immunol 2011 (Disease Models, Animal...) : Furthermore, SAA drives production of IL-1a, IL-1ß, IL-6, IL-23, and PGE ( 2 ), causes dendritic cell ( DC ) maturation, and requires TLR2 , MyD88, and the NLRP3 inflammasome for secretion of IL-1ß by DCs and macrophages