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EPHB2 — MET

Text-mined interactions from Literome

Maroun et al., Mol Cell Biol 2000 : Moreover, SHP-2 catalytic activity is required, since the expression of a catalytically inactive SHP-2 mutant, C/S, abrogates sustained activation of Erk and epithelial morphogenesis by the Met receptor
Taher et al., Biochem Biophys Res Commun 2002 (Arteriosclerosis...) : Stimulation with HGF led to activation of Met as well as to activation of PI3-K, PKB/Akt, MEK, and the MAP kinases Erk1 and -2
Fu et al., Nutr Cancer 2003 (Neoplasm Invasiveness...) : Met deprivation inhibits phosphorylation but not protein expression of FAK and ERK in PC3
Wang et al., Biochem Biophys Res Commun 2004 : A novel MET interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET induced Ras/Erk signaling
Bigelow et al., Oncogene 2006 (Breast Neoplasms...) : Pretreatment of cells with concentrations of EGCG as low as 0.3 microM inhibited HGF induced Met phosphorylation and downstream activation of AKT and ERK
Lee et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : In HCC cell lines, Spry2 overexpression inhibits c-Met induced cell proliferation as well as ERK and AKT activation, whereas loss of Spry2 potentiates c-Met signaling
Xu et al., J Biol Chem 2011 : Expression of RPTP-ß in primary human keratinocytes reduces both basal and HGF induced Met phosphorylation at tyrosine 1356 and inhibits downstream MEK1/2 and Erk activation
Brusevold et al., J Oral Pathol Med 2012 (Carcinoma, Squamous Cell...) : In the E10 cell line, EGF and HGF induced phosphorylation of EGF receptor (EGFR) and Met , respectively, phosphorylation of ERK1/2 , p38 and Akt, and dose dependent activation of cell migration
Soong et al., J Cell Sci 2013 : Functional studies showed that blockade of Shp2 activity abrogated MET dependent activation of Erk1/Erk2 and Akt in melanocytes