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EPHB2 — GAB1

Text-mined interactions from Literome

Cunnick et al., J Biol Chem 2000 : Conversely, expression of the wild-type Gab1 in HEK293 cells augmented the LPA receptor Edg2 mediated ERK2 activation ... These results establish a role for Gab1 in the LPA induced MAP kinase pathway and clearly demonstrate that Gab1-SHP2 interaction is essential for ERK2 activation by LPA and EGF
Cunnick et al., J Biol Chem 2001 : To investigate the mechanism by which Gab1 and SHP2 mediate ERK activation, we characterized the Gab1-SHP2 interaction ... Thus, physical association of activated SHP2 with Gab1 is necessary and sufficient to mediate the ERK mitogen activated protein kinase activation
Bisotto et al., Biochem J 2001 : Thus we determined whether Gab1 regulated ET-1 induced ERK1 activation ... Overexpression of wild-type Gab1 potentiated ET-1 induced activation of ERK1
Yu et al., J Biol Chem 2002 : ERK negatively regulates the epidermal growth factor mediated interaction of Gab1 and the phosphatidylinositol 3-kinase ... These experiments demonstrate that EGF and HGF mediated ERK activation result in divergent effects on Gab1/PI3K signaling
Koncz et al., Immunol Lett 2002 : Since ERK is regulated by the phosphorylated Gab1/2 , these data demonstrate that BCR triggered phosphorylation and signal amplification of Gab1/2 is a critical step in a life or death decision of B cells
Kim et al., Endocrinology 2002 : Notably, neither the ERK nor the STAT5 GH-dependent signaling outcome is affected by expression of the Gab1 mutant with tyrosine 627 changed to phenylalanine ... Our results suggest selective involvement of Gab1 in GH-induced ERK activation and implicate the Gab1 PH domain as critical in this involvement
Chan et al., J Biol Chem 2003 : Finally, the increased phosphorylation of Gab1 by Src selectively potentiated HGF induced activation of ERK and AKT
Ren et al., J Biol Chem 2004 : Importantly, Gab1FF blocked paxillin-SHP2 complex formation, Src Tyr-530 dephosphorylation, Erk activation, and cell migration induced by EGF
Kallin et al., J Biol Chem 2004 : Increased Gab1 expression enhanced the recruitment and activation of SHP-2, as well as the phosphorylation of the mitogen activated protein kinases Erk and p38 by PDGF
Osawa et al., J Biol Chem 2004 : In addition, reduction of Gab1 expression by antisense Gab1 oligos or overexpression of deltaNLS-Gab1 inhibited serum induced ERK1/2 and Egr-1 nuclear accumulation, suggesting a functional role for the NLS of Gab1 and a role for Gab1-ERK1/2 interactions in ERK1/2-Egr-1 nuclear accumulation ... To investigate whether Gab1-ERK1/2 interaction is critical for ERK1/2 and Egr-1 nuclear accumulation, we created a dominant negative Gab1 construct that consisted of the c-Met binding domain ( amino acids 442-536 ) of Gab1 ... We found that overexpression of the c-Met binding domain of Gab1 disrupted serum induced Gab1-ERK1 interaction and inhibited ERK1 and Egr-1 nuclear accumulation
Hayakawa-Yano et al., Stem Cells 2007 : Our in vitro analysis further revealed that Gab1 is essential for EGF dependent proliferation of Olig2 ( + ) progenitor cells derived from the E12.5 ventral and E14.5 dorsal but not ventral spinal cord, whereas Gab1 is always required for the activation of Akt1 but not of ERK1/2
Fukumoto et al., Cell Signal 2009 (Leukemia, Erythroblastic, Acute) : The co-immunoprecipitation experiments using the Jak inhibitor AG490 or siRNA duplexes targeting Jak2 and in vitro binding experiments demonstrated that Jak2 regulated Gab1 mediated Erk activation through tyrosine phosphorylation of Gab1
Takahashi-Tezuka et al., Mol Cell Biol 1998 : Expression of Gab1 enhanced gp130 dependent mitogen activated protein ( MAP ) kinase ERK2 activation ... A mutation of tyrosine 759, the SHP-2 binding site of gp130, abrogated the interactions of Gab1 with SHP-2 and PI-3 kinase as well as ERK2 activation ... These observations suggest that Gab1 acts as an adapter molecule in transmitting signals to ERK MAP kinase for the cytokine receptor gp130 and that SHP-2, PI-3 kinase, and Ras are involved in Gab1 mediated ERK activation