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CBL — EPHB2

Text-mined interactions from Literome

McCarty et al., J Recept Signal Transduct Res 1999 : In contrast, mutation of Y785 does not significantly affect BDNF-inducible Shc phosphorylation, ERK1/2 activation, or c-fos protein synthesis, but completely inhibits the tyrosine phosphorylation of PLCgamma and Cbl
Fong et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Furthermore, individually mutating hSpry2 residues 52-59 to alanine indicated a tight correlation between their affinity for c-Cbl binding and their inhibition of ERK2 activity in the FGFR pathway
Zhang et al., J Immunol 2004 (Calcium Signaling...) : The absence of c-Cbl increased the phosphorylation of ERK after receptor stimulation, but resulted in slightly reduced p38 phosphorylation and Ca ( 2+ ) response
Gustin et al., J Immunol 2006 : However, loss of Cbl-b does not enhance the activation of ERK or Akt, nor does it promote a greater calcium response
Qu et al., FEBS Lett 2009 (Cell Transformation, Neoplastic...) : Moreover, overexpression of Cbl-b significantly suppressed ERK activation, and Cbl-b ( DN ) strongly enhanced both ERK and Akt activation
Eisinger et al., J Biol Chem 2009 (MAP Kinase Signaling System) : Conversely, overexpression of c-Src as well as down-regulation of c-Cbl by small interfering RNA results in persistent etorphine induced stimulation of ERK1/2 activity
Qu et al., Mol Cell Biochem 2010 (Leukemia, Basophilic, Acute) : On the other hand, ERK activity was enhanced by Cbl-b , and the ERK inhibitor PD98059 reversed Cbl-b enhanced apoptosis
Sévère et al., J Biol Chem 2011 : Analysis of molecular mechanisms revealed that the Cbl mutant increased PDGF receptor a and FGF receptor 2 but not EGF receptor expression in hMSCs, resulting in increased ERK1/2 and PI3K signaling
Li et al., Mol Med Report 2011 (Lung Neoplasms) : Cbl regulated Akt and ERK signals are involved in ß-elemene induced cell apoptosis in lung cancer cells
Yan et al., J Cancer Res Clin Oncol 2012 (Breast Neoplasms...) : Moreover, down-regulation of Cbl-b by shRNA led to stronger activation of ERK , JNK and p38 MAPK, more up-regulation of DR4 and DR5, and a stronger synergistic effect of bufalin and TRAIL
Samoylenko et al., Carcinogenesis 2012 (Adenocarcinoma...) : Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src, Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Miranti et al., Curr Biol 1998 : This pathway may regulate multiple downstream events in hematopoietic cells, including Rac induced lamellipodia formation, tyrosine phosphorylation of Cbl , and activation of JNK, ERK2 and the phosphatidylinositol 3'-kinase regulated kinase Akt