Gene interactions and pathways from curated databases and text-mining

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LIF — TNF

Text-mined interactions from Literome

Piquet-Pellorce et al., Endocrinology 2000 : While LIF production was greatly enhanced in presence of serum, lipopolysaccharide, and TNFalpha further increased this production in peritubular and Sertoli cells, and human CG enhanced Leydig cell LIF production
Yu et al., J Cell Physiol 2007 : Despite the increase of gp130, TNF caused a significant reduction in the cell binding and endocytosis of leukemia inhibitory factor (LIF) , another proinflammatory cytokine that binds to the gp130 co-receptor and its unique gp190 receptor
Alter et al., J Biol Chem 2008 : Expression of IL-6 and leukemia inhibitory factor (LIF) was induced by TNFalpha in wild-type and JNK2-null myoblasts ... However, LIF expression was not induced by TNFalpha in JNK1-null myoblasts
Hendriks et al., J Neuroimmunol 2008 : LIF inhibits the production of oxygen radicals and TNFalpha and stimulates myelin uptake by macrophages
Levy et al., J Cell Biochem 2010 : We determined that TNFalpha treatment induced c-fos transcription, and blocking AP-1 activity resulted in a significant inhibition of TNFalpha induced LIF expression
Arici et al., J Clin Endocrinol Metab 1995 : On the other hand, we showed that interleukin-1, tumor necrosis factor-alpha , platelet derived growth factor, epidermal growth factor, and transforming growth factor-beta are potent inducers of LIF expression in endometrial stromal cells in culture in a concentration- and time dependent manner
Waring et al., Am J Obstet Gynecol 1994 (Bacterial Infections) : In cultured human gestational tissue explants, leukemia inhibitory factor release was significantly enhanced by endotoxin, interleukin-1 alpha, and tumor necrosis factor-alpha however, leukemia inhibitory factor did not enhance the release of prostaglandin E2 by these tissues
Hamilton et al., J Immunol 1993 : Induction of leukemia inhibitory factor in human synovial fibroblasts by IL-1 and tumor necrosis factor-alpha
Campbell et al., Arthritis Rheum 1993 (Arthritis, Rheumatoid) : Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) stimulated LIF production by chondrocyte monolayers and cartilage
Jansen et al., J Immunol 1996 (Escherichia coli Infections...) : In addition, to assess the role of TNF-alpha in the induction of LIF in vivo, seven baboons were studied that had either received a bolus injection of recombinant human TNF-alpha ( 100 micrograms/kg, n=3 ), or to whom 15 mg/kg of an anti-TNF mAB before lethal E. coli challenge was administered ( n=4 )
Billingsley et al., Ann Surg Oncol 1996 (Cachexia...) : 4JK tumor was further tested to determine if IL-1, tumor necrosis factor (TNF) , or cocultivation with RAW 264 cells augmented IL-6 or LIF production
Henrotin et al., Osteoarthritis Cartilage 1996 : IL-beta and TNF alpha highly stimulated IL-6, LIF and IL-8 productions
Keltz et al., Am J Obstet Gynecol 1996 (Pregnancy, Ectopic) : Interleukin-1 alpha, tumor necrosis factor-alpha , and transforming growth factor-beta enhanced leukemia inhibitory factor expression in epithelial and stromal cells, with transforming growth factor-beta 1 enhancing expression by fourfold in stromal cells ... Yet stromal cells treated with transforming growth factor-beta alone or in combination with epidermal growth factor and platelet derived growth factor, as well as TNF-alpha alone or in combination with interleukin-1 alpha enhanced secretion of leukemia inhibitory factor at or above the levels found with epithelial cells
Auernhammer et al., Endocrinology 1998 : In conclusion, corticotroph LIF mRNA expression is specifically stimulated by IL-1beta and tumor necrosis factor-alpha