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LIF — TNF
Text-mined interactions from Literome
Piquet-Pellorce et al., Endocrinology 2000
:
While
LIF production was greatly enhanced in presence of serum, lipopolysaccharide, and
TNFalpha further
increased this production in peritubular and Sertoli cells, and human CG enhanced Leydig cell LIF production
Yu et al., J Cell Physiol 2007
:
Despite the increase of gp130,
TNF caused a significant reduction in the cell binding and endocytosis of
leukemia inhibitory factor (LIF) , another proinflammatory cytokine that binds to the gp130 co-receptor and its unique gp190 receptor
Alter et al., J Biol Chem 2008
:
Expression of IL-6 and
leukemia inhibitory factor (LIF) was
induced by
TNFalpha in wild-type and JNK2-null myoblasts ... However,
LIF expression was not
induced by
TNFalpha in JNK1-null myoblasts
Hendriks et al., J Neuroimmunol 2008
:
LIF inhibits the production of oxygen radicals and
TNFalpha and stimulates myelin uptake by macrophages
Levy et al., J Cell Biochem 2010
:
We determined that TNFalpha treatment induced c-fos transcription, and blocking AP-1 activity resulted in a significant inhibition of
TNFalpha induced
LIF expression
Arici et al., J Clin Endocrinol Metab 1995
:
On the other hand, we showed that interleukin-1,
tumor necrosis factor-alpha , platelet derived growth factor, epidermal growth factor, and transforming growth factor-beta are potent
inducers of
LIF expression in endometrial stromal cells in culture in a concentration- and time dependent manner
Waring et al., Am J Obstet Gynecol 1994
(Bacterial Infections) :
In cultured human gestational tissue explants, leukemia inhibitory factor release was significantly
enhanced by endotoxin, interleukin-1 alpha, and
tumor necrosis factor-alpha however,
leukemia inhibitory factor did not enhance the release of prostaglandin E2 by these tissues
Hamilton et al., J Immunol 1993
:
Induction of
leukemia inhibitory factor in human synovial fibroblasts by IL-1 and
tumor necrosis factor-alpha
Campbell et al., Arthritis Rheum 1993
(Arthritis, Rheumatoid) :
Interleukin-1 (IL-1) and
tumor necrosis factor alpha (TNF alpha) stimulated
LIF production by chondrocyte monolayers and cartilage
Jansen et al., J Immunol 1996
(Escherichia coli Infections...) :
In addition, to assess the
role of
TNF-alpha in the induction of
LIF in vivo, seven baboons were studied that had either received a bolus injection of recombinant human TNF-alpha ( 100 micrograms/kg, n=3 ), or to whom 15 mg/kg of an anti-TNF mAB before lethal E. coli challenge was administered ( n=4 )
Billingsley et al., Ann Surg Oncol 1996
(Cachexia...) :
4JK tumor was further tested to determine if IL-1,
tumor necrosis factor (TNF) , or cocultivation with RAW 264 cells
augmented IL-6 or
LIF production
Henrotin et al., Osteoarthritis Cartilage 1996
:
IL-beta and
TNF alpha highly
stimulated IL-6,
LIF and IL-8 productions
Keltz et al., Am J Obstet Gynecol 1996
(Pregnancy, Ectopic) :
Interleukin-1 alpha,
tumor necrosis factor-alpha , and transforming growth factor-beta
enhanced leukemia inhibitory factor expression in epithelial and stromal cells, with transforming growth factor-beta 1 enhancing expression by fourfold in stromal cells ... Yet stromal cells treated with transforming growth factor-beta alone or in combination with epidermal growth factor and platelet derived growth factor, as well as
TNF-alpha alone or in combination with interleukin-1 alpha
enhanced secretion of
leukemia inhibitory factor at or above the levels found with epithelial cells
Auernhammer et al., Endocrinology 1998
:
In conclusion, corticotroph
LIF mRNA expression is specifically
stimulated by IL-1beta and
tumor necrosis factor-alpha