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AHSA1 — CDKN1A

Text-mined interactions from Literome

Alderton et al., Mol Pharmacol 2001 : High-intensity p38 kinase activity is critical for p21 ( cip1 ) induction and the antiproliferative function of G ( i ) protein coupled receptors
Otterbein et al., Nat Med 2003 (Arteriosclerosis) : The anti-proliferative effect of CO in vitro requires the activation of guanylate cyclase, the generation of cGMP, the activation of p38 mitogen activated protein kinases and the expression of the cell cycle inhibitor p21Cip1
Liu et al., Oncogene 2004 (Stomach Neoplasms) : The levels of HO-1 and p21 induced were significantly inhibited by p38 mitogen activated protein kinase ( p38 MAPK ) inhibitor ( SB203580 ) and extracellular regulated kinase (ERK) inhibitor ( PD098059 )
Todd et al., Oncogene 2004 : The ERK1/2 and p38alphabeta pathways cooperated to induce p21CIP1 expression and inhibition of p38alphabeta caused a partial reversal of the cell cycle arrest
Chen et al., J Cell Biochem 2004 (Carcinoma, Papillary...) : The induced levels of HO-1 and p21 were significantly reduced by p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular regulated kinase (ERK) inhibitors
Kim et al., Gastroenterology 2005 (MAP Kinase Signaling System) : The signaling pathway for colonocyte apoptosis following toxin A exposure involves p38 dependent activation of p53 and subsequent induction of p21 ( WAF1/CIP1 ), resulting in cytochrome c release and caspase-3 activation through Bak induction
Yang et al., FASEB J 2006 (MAP Kinase Signaling System) : CSE mediated apoptosis was associated with an increased ERK and p38 MAPK activation , up-regulation of p21 ( Cip/WAK-1 ), and down-regulation of cyclin D1 expression
Fan et al., Mol Cells 2007 : Suppression of p38 activation by SB203580 reduced the extent of apoptosis of the HeLa cells and also prevented induction of p21 , release of cytochrome c, and cleavage of caspase-3 and PARP
Pang et al., J Cell Physiol 2008 : Our study demonstrated that both the functional DRE and the phosphorylation of p38MAPK are essential for the induction of p21 and p27, resulting in the antiproliferative action of 3MC in HUVECs
Sau et al., Molecular bioSystems 2012 (Osteosarcoma) : These mitogen activated protein kinases ( MAPKs ) mediate different effects : JNK is crucial for apoptosis, whereas p38 causes an increase in the p21 level and a concomitant cell cycle arrest
Xiao et al., Leuk Res 2013 (Myelodysplastic Syndromes) : The increases were associated with an elevated expression of p21 but not the activation of p38