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CDKN1A — PIK3CA
Text-mined interactions from Literome
Mitsuuchi et al., Cancer Res 2000
(Ovarian Neoplasms) :
Experiments with additional ovarian carcinoma cell lines revealed that
PI3K is
involved in the expression of
p21 induced by cisplatin or paclitaxel in OVCAR-10 cells, which have wild-type p53, but not in OVCAR-5 cells, which lack functional p53
Linnemann et al., Virology 2002
:
Moreover,
PI3K was
required to activate the Nef associated
p21 activated kinase (PAK)
Gao et al., Am J Physiol Cell Physiol 2004
(Ovarian Neoplasms) :
Expression of the cyclin kinase inhibitor p16(INK4a) was
induced by the
PI3K inhibitor, whereas steady-state levels of
p21 ( CIP1/WAF1 ) were decreased in the same experiment
Lu et al., Int J Oncol 2006
(Prostatic Neoplasms) :
PI3K-Akt signaling is
involved in the regulation of
p21 ( WAF/CIP ) expression and androgen independent growth in prostate cancer cells
Pivoriūnas et al., Mol Cell Biochem 2007
(Leukemia) :
Here, we report a novel finding that
PI 3-K inhibition by LY294002 significantly
increases p21WAF1/Cip1 expression in PMA stimulated human leukemia cells NB4 and THP1
Xia et al., J Biol Chem 2007
(Neoplasms) :
Collectively, these findings demonstrate that
p21 ( RAS ), through its downstream effector
PI3K ,
induces PKCdelta expression and that this increase in PKCdelta activity, acting through Akt, is required for cell survival
Xing et al., American journal of physiology. Renal physiology 2008
:
In contrast, PP1 and
PI3K inhibition
had no effect on cyclin E and
p21
Li et al., Biomed Environ Sci 2010
:
Activation of
PI3K/Akt1 pathway and subsequent negative
regulation of
p21 ( WAF1/CIP1 ) and p27 ( KIP1 ) expression might be involved in CagA associated carcinogenesis
Yohn et al., BMC urology 2011
(Carcinoma, Transitional Cell...) :
Phosphatidylinositol 3'-kinase , mTOR, and glycogen synthase kinase-3ß
mediated regulation of
p21 in human urothelial carcinoma cells