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MTTP — TNF
Text-mined interactions from Literome
Dieter et al., Mediators Inflamm 1999
:
LPS and
MTP-PE ( liposome encapsulated N-acetyl-muramyl-L-alanyl-D-isoglutaminyl-L-alanine-2- : [ 1',2'dipalmitoyl -sni-glycero-3- ( hydroxy-phosphoryl-oxyl ) ] etylamide )
induce in liver macrophages a synthesis and release of
TNF-alpha , nitric oxide and prostanoids ... Inhibition of NF-kappaB inhibits the LPS- but not the
MTP-PE induced release of
TNF-alpha , nitric oxide and PGE2 ... Exogenously added PGE2 inhibits the
activation of map kinase and
TNF-alpha release by LPS, but not by
MTP-PE
Tafani et al., Am J Pathol 2000
:
These data indicate that
induction of the
MTP by
TNF-alpha causes a release of cytochrome c, caspase-3 activation with PARP cleavage and DNA fragmentation
Dieter et al., J Immunol 1995
:
LPS and liposome encapsulated
MTP-PE induce liver macrophages cytotoxicity against tumor target cells and a release of
TNF-alpha , nitric oxide, and eicosanoids but not a generation of superoxide anions
Landmann et al., Biotherapy 1993
(Carcinoma, Renal Cell...) :
MTP-PE caused a marked increase of serum
TNFa , IL-1 receptor antagonist (IL-1ra) and IL-6 in week 1, but not thereafter
Asano et al., Cancer Immunol Immunother 1994
:
We have already reported that
L-MTP-PE induced monocyte mediated tumoricidal activity and up-regulation of the
tumor necrosis factor and interleukin-1 (IL-1) in vivo and in vitro
Durham et al., J Surg Res 1998
(Bacteremia...) :
Effect of
MTP on
TNF-alpha in perfused rat liver after bacteremia and ischemia/reperfusion ...
MTP increased bioactive
TNF-alpha response to EC ( MTP + EC vs EC controls : 685 +/- 255 U/ml vs 250 +/- 180 U/ml, P < 0.02 )