Gene interactions and pathways from curated databases and text-mining

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ABL1 — TNF

Text-mined interactions from Literome

Chau et al., Mol Cell Biol 2004 : Tumor necrosis factor alpha induced apoptosis requires p73 and c-ABL activation downstream of RB degradation ... In cells expressing a degradation-resistant RB protein ( RB-MI ), TNF-alpha does not activate c-ABL
Wang et al., Cell Res 2005 (Inflammation) : Thus, Rb inactivation is a pre-requisite for Abl activation by DNA damage or TNF
Le et al., J Immunol 1998 : In this study, we showed that reduction of c-Abl in macrophages prevented LPS induced growth arrest, nitric oxide production and TNF-alpha secretion by ANA-1 macrophages