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IL17D — IL2

Text-mined interactions from Literome

Owaki et al., J Immunol 2006 : In this study we demonstrate that IL-27 inhibits CD28 mediated IL-2 production and that suppressor of cytokine signaling 3 ( SOCS3 ) plays a critical role in the inhibitory effect ... Although IL-27 enhanced IFN-gamma production from naive CD4+ T cells stimulated with plate coated anti-CD3 and anti-CD28 in the presence of IL-12, IL-27 simultaneously inhibited CD28 mediated IL-2 production ... These results suggest that IL-27 inhibits CD28 mediated IL-2 production and also IL-2 responses, and that SOCS3, whose expression is induced by IL-27, plays a critical role in the inhibitory effect in a negative feedback mechanism
Shen et al., Scand J Rheumatol 2013 (Behcet Syndrome...) : Elevated levels of interleukin-27 and effect on production of interferon-? and interleukin-17 in patients with Behçet 's disease