Gene interactions and pathways from curated databases and text-mining

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CRKL — EPX

Text-mined interactions from Literome

Arai et al., J Biol Chem 2001 : Overexpression of Lyn induced constitutive phosphorylation of CrkL and activation of Erk, whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of Erk
Chin et al., Biochem Biophys Res Commun 1997 : Studies using cells expressing mutant EpoRs showed that the Epo induced tyrosine phosphorylation of CrkL is dependent on the membrane-proximal EpoR cytoplasmic region involved in the activation of Jak2 as well as the C-terminal 145 amino acid region which is required for tyrosine phosphorylation of SHP-2 and Shc