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ADCYAP1 — TH

Text-mined interactions from Literome

Choi et al., Peptides 1999 : PACAP increased tyrosine hydroxylase and dopamine beta-hydroxylase activities, but slightly lowered phenylethanolamine N-methyltransferase activity, resulting in a preferential rise in norepinephrine over epinephrine
Nanmoku et al., Biochem Biophys Res Commun 2000 (Adrenal Gland Neoplasms...) : Orexin-A and -B ( 100 nM ) significantly reduced basal and PACAP induced tyrosine hydroxylase (TH) ( the rate limiting enzyme in the biosynthesis of catecholamines ) mRNA levels
Tohei et al., Neuroendocrinology 2001 : The effects of PACAP6-38 on PRL and oxytocin secretion, and on the activity of tyrosine hydroxylase (TH) , were examined after the onset of suckling
Brandish et al., Neuron 2005 : Previous work has shown that PACAP can increase tyrosine hydroxylase (TH) activity and dopamine release, and we found that the gene for GTP cyclohydrolase, which effectively regulates TH through synthesis of tetrahydrobiopterin, was also upregulated by inositol depletion
Bobrovskaya et al., Cell Signal 2007 : PACAP stimulates the sustained phosphorylation of tyrosine hydroxylase at serine 40
Houchi et al., Jpn J Pharmacol 1994 : Catecholamine synthesis and tyrosine hydroxylase phosphorylation stimulated by the maximal effective concentration of dibutyryl cAMP or high K+, which activates Ca2+ uptake, were further enhanced by PACAP , suggesting that both cAMP- and Ca ( 2+ ) -dependent protein kinases may be involved in the stimulation of tyrosine hydroxylase phosphorylation and catecholamine synthesis caused by PACAP
Houchi et al., Hypertens Res 1995 : Dopamine synthesis and tyrosine hydroxylase phosphorylation stimulated by the maximal effective concentration of dibutyryl cAMP or high K+, which activates Ca2+ uptake, were further enhanced by PACAP1-38
Marley et al., J Auton Nerv Syst 1996 : PACAP-27 increased tyrosine hydroxylase activity 3-fold over 10 min ... In the absence of extracellular Ca2+, chelation of intracellular Ca2+ by treating cells with BAPTA-AM ( 50 microM ) caused a consistent 40-50 % reduction in basal tyrosine hydroxylase activity and in the responses to forskolin and PACAP-27
Haycock et al., Ann N Y Acad Sci 1996 : Short- and long-term regulation of tyrosine hydroxylase in chromaffin cells by VIP and PACAP
Muller et al., J Neurochem 1997 : Both forms of PACAP , as well as forskolin, stimulated transcriptional induction of tyrosine hydroxylase (TH) and c-fos promoters fused to a chloramphenicol acetyltransferase (CAT) reporter gene in transiently transfected cells ( p < 0.01 vs. controls )
Gonzalez et al., Ann Endocrinol (Paris) 1998 : In the brain, PACAP stimulates the electrical activity of various populations of neurons and increases tyrosine hydroxylase gene expression