Schneider et al., J Immunol 2002
(MAP Kinase Signaling System) :
Ab ligation studies have reported an inhibitory effect of CTLA-4 on TCR induced ERK and JNK activation
Chikuma et al., J Immunol 2005
(Lymphoproliferative Disorders) :
Expression of a B7-nonbinding CTLA-4 mutant inhibited T cell proliferation, cytokine production, and TCR mediated ERK activation in otherwise CTLA-4-deficient T cells