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IFNG — IL2RA

Text-mined interactions from Literome

Bellinghausen et al., J Allergy Clin Immunol 2003 (Hypersensitivity) : In some atopic patients preactivated CD4 ( + ) CD25 ( + ) T cells reproducibly showed strong proliferative responses, produced higher amounts of IL-4 and IL-10 than CD4 ( + ) CD25 ( - ) T cells, and suppressed only the IFN-gamma production of CD4 ( + ) CD25 ( - ) T cells
Scott et al., J Immunol 2003 (Chronic Disease...) : HIV-1 gag p55-specific CD4 ( + ) T cell IFN-gamma responses were detected in the majority of children studied
Fu et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2003 : This article reviews that as a functionally and phenotypically distict immunoregulatory T cell subpopulation, CD4 ( + ) CD25 ( + ) regulatory T cells can suppress the activation and proliferation of CD4 ( + ) CD25 ( - ) T cells and CD8 ( + ) T cells and the production of IL-2 and IFN-gamma
Lew et al., Br J Dermatol 2004 (Disease Progression...) : The mRNA expression of keratin 16, CD25 , IFN-gamma, IL-12 p40, signal transducer and activator of transcription-1, inducible nitric oxide synthase, IL-8, macrophage inflammatory protein-3alpha, monocyte chemoattractant protein-1, S100A12, IFN-gamma-inducible protein of 10 kDa, IFN-inducible T-cell alpha-chemoattractant and monokine induced by IFN-gamma was increased in the lesions of both LP psoriasis and SP psoriasis
Zenclussen et al., Am J Pathol 2005 (Abortion, Spontaneous) : Very interestingly, CD4 ( + ) CD25 ( + ) Treg cells from normal pregnant and nonpregnant CBA/J mice could inhibit both proliferation and interferon-gamma secretion of lymphocytes from abortion mice in vitro whereas in vivo prevention of fetal rejection could only be achieved after adoptive transfer of Treg cells from normal pregnant mice
Benghiat et al., Transplantation 2005 : Finally, natural CD25 ( + ) Treg cells inhibited the production of interleukin (IL)-2, interferon-gamma , IL-5, and IL-13 in mixed lymphocyte culture in a dose dependent manner
Yu et al., Zhong Yao Cai 2005 : the immunosuppressive mechanism of TRD may be related to the inhibitory effects on IL-2 and IFN-gamma mRNA expression and the inhibition of CD69 and CD25 expression
Manigold et al., Blood 2006 (Hepatitis C) : Foxp3 ( + ) CD4 ( + ) CD25 ( + ) T ( Regs ) suppressed IFN-gamma production, expansion, and activation induced cell death of HCV-specific T cells after recovery from HCV infection and in persistent HCV infection
Yang et al., Zhonghua Nei Ke Za Zhi 2006 (Hepatitis C, Chronic) : CD(4) ( + ) CD(25) ( + ) Treg cells highly expressed Foxp3 and mainly synthesized IL-10 ; CD(4) ( + ) CD(25) ( + ) Treg cells dramatically suppressed the proliferation of CD(4) ( + ) T cells and the production of IFN gamma ; the suppressive activity of CD(4) ( + ) CD(25) ( + ) Treg cells in patients with persistent HCV-infection was higher than that in healthy controls ( P = 0.034 )
Lu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2006 : In vitro CD4 ( + ) CD25 ( + ) T cells could suppress the proliferation of CD4 ( + ) CD25 ( - ) T cells and IFN-gamma , IL-2 production, but they themselves could secrete IL-10
Takahara et al., Int J Cancer 2006 : IL-10 treatment enhanced , while IFN-gamma receptor blocking antibody reduced, the expression of CD25 and CD54 in the EBV positive, but not in the EBV negative lines
Chen et al., J Biol Chem 2006 : Ectopic expression of Foxp3 in non-T ( reg ) leads to repression of the interleukin 2 (IL-2) and interferon gamma (IFNgamma) genes, gain of suppressor function, and induction of genes such as CD25 , GITR, and CTLA-4, but the mode by which Foxp3 enforces this program is unclear
Visser et al., Clin Exp Immunol 2007 (Cervical Intraepithelial Neoplasia...) : Moreover, in HPV16 ( + ) cervical cancer patients, in-vitro depletion of CD25 ( + ) T cells resulted in increased IFN-gamma T cell responses against HPV16 E6- and E7 peptides
Park et al., J Leukoc Biol 2009 (Alveolitis, Extrinsic Allergic) : Moreover, IL-10 production of CD4 ( + ) CD25 ( + ) T ( reg ) cells and direct contact between CD4 ( + ) CD25 ( + ) T ( reg ) cells and CD4 ( + ) or CD8 ( + ) T cells in BALF resulted in reduced IFN-gamma production
Fogle et al., AIDS Res Hum Retroviruses 2010 (Cat Diseases...) : CD4 ( + ) CD25 ( + ) T regulatory cells inhibit CD8 ( + ) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta dependent mechanism ... Depletion of CD4 ( + ) CD25 ( + ) lymphocytes from lymph node suspensions significantly enhanced production of IFN-gamma during the acute phase of infection and coculture of CD8 ( + ) lymphocytes with CD4 ( + ) CD25 ( + ) lymphocytes resulted in suppression of CD8 ( + ) IFN-gamma during both the acute and chronic stages of infection