Feng et al., J Renin Angiotensin Aldosterone Syst 2001
(Carotid Artery Injuries) :
Both ACE inhibition and AT, -receptor blockade had marked effects on plasma levels of endothelin ET1, thromboxane TXB2 and 6-keto-PGF1-alpha Gryglewski et al., Prostaglandins Leukot Essent Fatty Acids 2005
(Disease Models, Animal...) :
In contrast, selective COX-2 inhibitors ( rofecoxib > > celecoxib > nimesulide > NS 398 ) were thrombogenic, and abolished THR and rise in 6-keto-PGF ( 1 alpha ) induced by ACE-Is. Summing up, in our in vivo bioassay system ACE-Is such as quinapril, perindopril or captopril at non-hypotensive doses evoke THR that is mediated by endogenous bradykinin and prostacyclin derived from endothelial COX-2