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PLA2G4A — PTGS1

Text-mined interactions from Literome

Yamasaki et al., Hypertension 2000 : Pretreatment with cycloheximide superinduced cPLA(2) and PGHS-2 mRNA expression but almost completely inhibited PGHS-1
Ishida et al., Am J Physiol Heart Circ Physiol 2011 (Diabetes Mellitus, Type 2...) : In arteries from GK rats ( vs. those from Wistar rats ), 1 ) ATP- and UTP induced contractions, which were blocked by the nonselective P2 antagonist suramin, were enhanced, and these enhancements were suppressed by endothelial denudation, by cyclooxygenase (COX) inhibitors, or by a cytosolic phospholipase A ( 2 ) ( cPLA(2) ) inhibitor ; 2 ) both nucleotides induced increased release of PGE ( 2 ) and PGF ( 2a ) ; 3 ) nucleotide stimulated cPLA(2) phosphorylations were increased ; 4 ) COX-1 and COX-2 expressions were increased ; and 5 ) neither P2Y2 nor P2Y6 receptor expression differed, but P2Y4 receptor expression was decreased