◀ Back to CDH1
CDH1 — MMP7
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin/Kaiso complex (CDH1-CTNND1-ZBTB33)
→
MMP7 (MMP7)
(transcription, activates)
Daniel et al., Nucleic Acids Res 2002*, Ferber et al., J Biol Chem 2008
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
MMP7 (MMP7)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Huguenin et al., PloS one 2008, Lynch et al., Journal of oncology 2010, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
MMP7 (MMP7)
→
sE-cad (CDH1)
(modification, activates)
Noë et al., J Cell Sci 2001, Huguenin et al., PloS one 2008, Lynch et al., Journal of oncology 2010, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
Reactome Reaction:
CDH1
→
MMP7
(reaction)
Text-mined interactions from Literome
Davies et al., Clin Cancer Res 2001
(Neoplasm Invasiveness...) :
Matrilysin mediates extracellular cleavage of
E-cadherin from prostate cancer cells : a key mechanism in hepatocyte growth factor/scatter factor induced cell-cell dissociation and in vitro invasion ... Both recombinant human
Matrilysin ( rh-Matrilysin ) and/or HGF/SF
increased the level of soluble
E-cadherin and decreased the level of full-length ( M ( r ) 120,000 ) E-cadherin as detected by Western blotting
Mei et al., Carcinogenesis 2002
:
The sum effect of MMP inhibitors demonstrated that NO-induced activation of
MMP may
cause the degradation of
E-cadherin and the subsequent dissociation of beta-catenin, thereby contributing to the cytosolic accumulation of beta-catenin and nuclear formation of beta-catenin/LEF-1 complex
McGuire et al., Am J Pathol 2003
(Fibrosis) :
Matrilysin ( matrix metalloproteinase-7 )
mediates E-cadherin ectodomain shedding in injured lung epithelium
Nawrocki-Raby et al., Am J Pathol 2003
(Bronchial Neoplasms...) :
E-Cadherin mediates
MMP down-regulation in highly invasive bronchial tumor cells
Wang et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2004
(Lymphatic Metastasis...) :
In the group of nasopharyngeal carcinoma with distant metastasis, the expression of
E-cadherin and nm23H1 also increased and the expression of CD44H,
MMP-3 and VEGF all
increased
Lee et al., Eur Surg Res 2007
(Adenocarcinoma...) :
We have investigated whether extracellular cleavage of
E-cadherin mediated by
matrix metalloproteinase-7 (MMP-7) is involved in hepatocyte growth factor (HGF) induced in vitro invasion in stomach cancer cells
Zhao et al., Cancer Lett 2013
(Neovascularization, Pathologic...) :
EA also reversed epithelial to mesenchymal transition by up-regulating
E-cadherin and
inhibiting the expression of Snail,
MMP-2 and MMP-9