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CYP7A1 — FOXO1
Text-mined interactions from Literome
Li et al., J Biol Chem 2006
:
Insulin regulation of
cholesterol 7alpha-hydroxylase expression in human hepatocytes :
roles of
forkhead box O1 and sterol regulatory element binding protein 1c
Li et al., J Lipid Res 2008
:
Smad3,
FoxO1 , and HNF4alpha synergistically
stimulated rat
Cyp7a1 gene transcription ... Smad3,
FoxO1 , and HNF4alpha synergistically
stimulated rat
Cyp7a1 gene transcription
Li et al., Biochim Biophys Acta 2009
(Insulin Resistance) :
This study investigated the
roles of
FoxO1 in the regulation of
cholesterol 7alpha-hydroxylase ( CYP7A1 ) gene expression in primary human hepatocytes ... Adenovirus mediated expression of a phosphorylation defective and constitutively active form of
FoxO1 ( FoxO1-ADA )
inhibited CYP7A1 mRNA expression and bile acid synthesis, while siRNA knockdown of FoxO1 resulted in a approximately 6-fold induction of CYP7A1 mRNA in human hepatocytes ... Insulin caused rapid exclusion of FoxO1 from the nucleus and resulted in the induction of
CYP7A1 mRNA expression, which was
blocked by
FoxO1-ADA ... Impaired regulation of
FoxO1 may
cause down-regulation of
CYP7A1 gene expression and contribute to dyslipidemia in insulin resistance
Park et al., Exp Mol Med 2011
:
However, ectopic expression of
FOXO1 increased the rat CYP7A1-, but mildly
reduced human
CYP7A1-promoter activities in a dose dependent manner