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PDE3B — PIK3CG
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Patrucco et al., Cell 2004
(Hypertension) :
Thus, cardiac
PI3Kgamma participates in two distinct signaling pathways : a kinase dependent activity that controls PKB/Akt as well as MAPK phosphorylation and contributes to TAC induced cardiac remodeling, and a kinase independent activity that relies on protein interactions to
regulate PDE3B activity and negatively modulates cardiac contractility
Voigt et al., J Biol Chem 2006
:
However, coexpression of PDE3B and PI3Kgamma subunits was not sufficient to reconstitute the regulatory
effect of
PI3Kgamma on
PDE3B activity observed in heart, implying further molecules to be present in the complex regulating PDE3B in heart
Perino et al., Biochem Soc Trans 2006
:
In this complex,
PI3Kgamma could
regulate PDE3B activity through protein kinase A, a PDE activator